Pregled bibliografske jedinice broj: 397168
Antioxidant activity of NSAID hydroxamic acids
Antioxidant activity of NSAID hydroxamic acids // Acta pharmaceutica, 59 (2009), 2; 235-242 doi:10.2478/v10007-009-0017-8 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 397168 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Antioxidant activity of NSAID hydroxamic acids
Autori
Zovko Končić, Marijana ; Rajić, Zrinka ; Petrić, Neva ; Zorc, Branka
Izvornik
Acta pharmaceutica (1330-0075) 59
(2009), 2;
235-242
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
NSAID; hydroxamic acid; antioxidant activity; radical scavenging activity; metal chelating activity
Sažetak
In the present study, seven hydroxamic acid derivatives of nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, fenoprofen, ketoprofen, indomethacin and diclofenac) were found to possess significant antioxidant, radical scavenging and metal chelating activities. The most active antioxidant and radical scavenger was N-methylhydroxamic acid of diclofenac (ANT = 88.0 % and EC50 = 60.1 mg mL– 1). The activity of the standard substance, butylated hydroxyanisole, in the two assays was ANT = 86.9 % and EC50 = 18.8 mg mL– 1, respectively. Ibuproxam was the strongest iron chelator among investigated hydroxamic acids (EC50 = 255.6 mg mL– 1), yet significantly weaker than the standard substance, EDTA (EC50 = 29.1 mg mL– 1). It seems that different mechanism is involved in metal chelating activity than in antioxidant and radical scavenging activity. Antioxidant and radical scavenging activities may be connected with conjugation of the nitrogen lone electron pair with the carbonyl group. On the other hand, more hydrophilic substances tend to be better iron chelators.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija
POVEZANOST RADA
Projekti:
006-0061246-1251 - Antioksidativni i prooksidativni učinak ljekovitih biljnih vrsta na hepatocite (Petlevski, Roberta, MZOS ) ( CroRIS)
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- International Pharmaceutical Abstracts (IPA)