Naslov
THE ROLE OF PERFORIN CYTOLITIC PATHWAY IN PATIENTS WITH OBSTRUCTIVE AND RESTRICTIVE SPIROMETRY’ S CHANGES

Autori
Bulog, A, ; Mrakovcic-Sutic, I, ; Micovic, V,

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Asthma-New Horizonts in Asthma and COPD Management and Prevention / Revaz I Sepiashvili - Moskva, 2009

Skup
2nd World Asthma and COPD Forum VII CIS Congress of Allergology and Immunology

Mjesto i datum
Sankt Peterburg, Ruska Federacija, 25.04.2009. - 28.04.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cytotoxicity; enviromental factors; Immune response; obstructive changes; perforin

Sažetak
Cytotoxic T lymphocytes and natural killer (NK) cells represent two major types of immune cytotoxic cells that have a crucial role in innate immunity eliminating pathogen-infected cells. Both of these cells have a possibility to kill by two distinct signal transduction pathways. The first is the granule exocytosis pathway mediated by direct releasing of cytotoxic granules (perforin and granzymes) into the synapse between the effector and target cell. Perforin and granzymes are stored in the cytoplasmic granules of the cytotoxic cells. After release, they complexes with the proteoglycan serglycin and enter the target cell inducing apoptosis by splitting a selected set of cellular proteins. The objectives of this study were to examine the release of cytolitic molecule perforin from peripheral blood lymphocytes of individuals living in industrial areas with detected spyrometry's changes (restrictive and/or obstructive). Results: our preliminary date has shown significant augmentation in the amount of total perforin, as well as the number of double positive (perforin positive and cell surface antigens positive cells), implicating the distinct mechanisms of immunoregulation in individuals living in urban industrial areas. Acknowledgement: This work was supported by grants from the Croatian Ministry of Science (No 0621341-0308 and 0620096-0094).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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