Pregled bibliografske jedinice broj: 395368
OVEREXPRESSION OF NKT CELLS INCREASES THE CELL-MEDIATED CYTOTOXICITY AGAINST TUMOR CELL LINES IN PATIENTS WITH ENVIRONMENTAL DISEASES
OVEREXPRESSION OF NKT CELLS INCREASES THE CELL-MEDIATED CYTOTOXICITY AGAINST TUMOR CELL LINES IN PATIENTS WITH ENVIRONMENTAL DISEASES // Asthma-New Horizonts in Asthma and COPD Management and Prevention, Vol 10, Supp.1, 2009 / Revaz I Sepiashvili (ur.).
Moskva, 2009. (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 395368 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
OVEREXPRESSION OF NKT CELLS INCREASES THE CELL-MEDIATED CYTOTOXICITY AGAINST TUMOR CELL LINES IN PATIENTS WITH ENVIRONMENTAL DISEASES
Autori
Mrakovcic-Sutic, I, ; Bulog, A, ; Micovic, V,
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Asthma-New Horizonts in Asthma and COPD Management and Prevention, Vol 10, Supp.1, 2009
/ Revaz I Sepiashvili - Moskva, 2009
Skup
2nd World Asthma and COPD Forum VII CIS Congress of Allergology and Immunology
Mjesto i datum
Sankt Peterburg, Ruska Federacija, 25.04.2009. - 28.04.2009
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
cytotoksicity; environmental diseases; NK cells; NKT cells; Tregs
Sažetak
Asthma is caused or enhanced by environmental factors such as allergen exposure and/or chronic exposure to vapors. The precise mechanisms that drive asthma remain unclear. It is dominated by presence of eosinophils and CD4 (+) T lymphocytes which induced inflammation with secretion of interleukin-4 and interleukin-13 and triggers the development of airway hyperreactivity. It is identified a new subset of T cells, natural killer T (NKT) cells, which share some common features, but to conventional CD4 (+) T cells, NKT cells do not respond to peptide antigens, but to glycolipids. They have crucial role in several disease states, from autoimmune diseases to cancer. The aim of this study was to investigate role of NKT cells in patients’ exposure to industrial vapors and correlate with function of NK cells (cytotoxicity assay against tumor cell line-K562). Results: All exposed individuals demonstrated the increased number of NKT cells in peripheral blood lymphocytes and significant augmentation of NK-mediated cytotoxicity against human NK-sensitive target. Conclusion: These data suggest that NKT cells play an important role in pathogenesis of diseases which possible inducible etiological marker is exposure to vapors. Acknowledgement: This work was supported by grants from the Croatian Ministry of Science (No 0620096-0094 and 0621341-0308).
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Projekti:
062-0620096-0094 - Regulacijske T i NKT stanice u kontroli tumorskog rasta, opeklina i autoimunosti (Mrakovčić-Šutić, Ines, MZOS ) ( CroRIS)
062-0621341-0308 - Odgovor ljudi i morskih organizama na ekološko zagađenje u Kvarnerskom zaljevu (Mićović, Vladimir, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
