Pregled bibliografske jedinice broj: 393831
The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats
The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats // BioMetals, 22 (2009), 6; 973-983 doi:10.1007/s10534-009-9249-9 (međunarodna recenzija, članak, znanstveni)
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Naslov
The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats
Autori
Lazarus, Maja ; Orct, Tatjana ; Jurasović, Jasna ; Blanuša, Maja
Izvornik
BioMetals (0966-0844) 22
(2009), 6;
973-983
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
cadmium; interaction; selenium; suckling rat; trace elements
Sažetak
Selenium (Se) reduces cadmium (Cd) toxicity in adult animals, but its effects in newborn animals are still unknown. This study investigated Cd (as CdCl2) absorption, distribution, and retention in suckling rats receiving oral Se supplementation (as Na2SeO3) in equimolar doses (8 μ mol Cd and/or Se per kg b.w./day). Selenium was given either before and during Cd exposure (Sepre+Cd group ; pre-treatment group) or only during Cd exposure (Se+Cd group). Rats were treated from postnatal day (PND) 6 to 14 as follows: controls (H2O, PND 6-14), Se (PND 10-14), Cd (PND 10-14), Sepre+Cd (Se PND 6-14 + Cd PND 10-14) and Se+Cd (Se + Cd PND 10-14). Selenium supplementation, especially pre-treatment, decreased Cd levels in the blood, brain, liver and kidney of suckling rats and Cd excretion. Selenium levels in plasma, brain, and kidney also decreased. These findings suggest that higher Se intake could efficiently reduce Cd retention during the suckling period.
Izvorni jezik
Engleski
Znanstvena područja
Javno zdravstvo i zdravstvena zaštita
Napomena
Published online: 5 June 2009 (Springer Link)
POVEZANOST RADA
Projekti:
022-0222148-2135 - Izloženost metalima i njihovi učinci u graviditetu i postnatalnom razdoblju (Piasek, Martina, MZOS ) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
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