Naslov
Bisalbuminemija kod bolesnika iz Hrvatske sa sarkoidozom
(Bisalbuminemia in a male Croatian patient with sarcoidosis)

Autori
Šimundić, Ana-Maria ; Miler, Marijana ; Nikolac, Nora ; Topić, Elizabeta ; čaržavec, Dubravka ; Milanović, Branka ; Stančić, Vladimir

Izvornik
Biochemia medica (1330-0962) 19 (2009), 1; 95-100

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz slučaja, znanstveni

Ključne riječi
bisalbuminemija; kapilarna zonska elektroforeza; genetička heterogenost; sarkoidoza; albumin u serumu
(bisalbuminemia; capillary zone electrophoresis; genetic heterogeneity; sarcoidosis; serum albumin)

Sažetak
Background: Inherited bisalbuminemia is rare, mostly benign state, which has been so far described in several pathological conditions. Two genetic variants have already been described in two Croatian families. Herein we report a new case of bisalbuminemia in a Croatian male patient with sarcoidosis. Methods: Patient was referred by a general practitioner to our hospital for a diagnostic work up for suspected sarcoidosis. Serum capillary protein electrophoresis was performed with automated capillary electrophoresis system. Results: Based on laboratory and pathologic findings, diagnosis of sarcoidosis was confirmed. Serum electrophoresis revealed two distinct albumin bands. Albumin variant was fast-migrating. Fast and normal band were 0.51 and 0.48 of the total albumin, respectively. Patient sister was also bisalbuminemic. Conclusions: This is a new case of inherited bisalbuminemia in a patient with sarcoidosis. Whether bisalbuminemia has any relevance to sarcoidosis, remains to be elucidated. Clinical chemists and clinicians should be alerted by every incident case of either inherited or acquired albumin variant, because it could provide insight into the protein evolution as well as the physical, chemical and molecular characteristics of albumin.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je objavljen na hrvatskom i na engleskom jeziku

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