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Pregled bibliografske jedinice broj: 392128

New therapeutic and experimental aspects of chelators as antidotes of metal toxicity

Varnai, Veda Marija; Blanuša, Maja; Piasek, Martina; Kostial, Krista
New therapeutic and experimental aspects of chelators as antidotes of metal toxicity // Frontiers in Medicinal Chemistry, Volume 4 / Atta-ur-Rahman ; Reitz, Allen B. (ur.).
Karachi: Bentham Science, 2009. str. 130-182

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Naslov
New therapeutic and experimental aspects of chelators as antidotes of metal toxicity

Autori
Varnai, Veda Marija ; Blanuša, Maja ; Piasek, Martina ; Kostial, Krista

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Frontiers in Medicinal Chemistry, Volume 4

Urednik/ci
Atta-ur-Rahman ; Reitz, Allen B.

Izdavač
Bentham Science

Grad
Karachi

Godina
2009

Raspon stranica
130-182

ISBN
90-77527-07-9

Ključne riječi
chelating agents, BAL derivatives, carbodithioates, deferiprone, deferoxamine, deferasirox, D-penicillamine, polyaminopolycarboxylic acids, metal toxicity, age

Sažetak
The clinical use of chelating drugs as antidotes for metal toxicity are reviewed, together with the in vivo effects of their synthetic homologues and new chelating agents. Concise facts on toxic effects of human exposure to metals are given for the following elements: lead, cadmium, mercury, manganese, aluminum, iron, copper, thallium, arsenic, chromium, nickel, and platinum. Pharmacokinetic data, clinical use and adverse effects of the majority of chelating drugs used in human metal poisoning, are briefly summarized, i.e. dimercaprol (BAL), succimer (meso-DMSA), unithiol (DMPS), D-penicillamine (DPA), N-acetyl-D-penicillamine (NAPA), calcium disodium ethylenediaminetetraacetate (CaNa2EDTA), calcium trisodium or zinc trisodium diethylenetriaminepentaacetate (CaNa3DTPA, ZnNa3DTPA), deferoxamine (DFO), deferiprone (L1), deferasirox (ICL670), triethylenetetraamine (trientine), N-acetylcysteine (NAC), and Prussian blue (PB). The in vivo effects of three groups of synthetic chelators, namely the polyaminopolycarboxylic acids (EDTA and DTPA), derivatives of BAL (DMPS, DMSA and mono- and dialkylesters of DMSA), and carbodithioates, are also described. Among the number of factors that can influence the efficacy of chelation treatment, modifying effects of age are shown, in light of experimental results in young and adult animals.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
Article on request. DOI:10.2174/90775270791040101. Indexed in: EMBASE (Excerpta Medica), Scopus, EMBiology



POVEZANOST RADA

Projekti:
022-0222148-2135 - Izloženost metalima i njihovi učinci u graviditetu i postnatalnom razdoblju (Piasek, Martina, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Martina Piasek (autor)

Avatar Url Krista Kostial-Šimonović (autor)

Avatar Url Veda Marija Varnai (autor)

Avatar Url Maja Blanuša (autor)

books.google.hr eurekaselect.com

Citiraj ovu publikaciju:

Varnai, Veda Marija; Blanuša, Maja; Piasek, Martina; Kostial, Krista
New therapeutic and experimental aspects of chelators as antidotes of metal toxicity // Frontiers in Medicinal Chemistry, Volume 4 / Atta-ur-Rahman ; Reitz, Allen B. (ur.).
Karachi: Bentham Science, 2009. str. 130-182
Varnai, V., Blanuša, M., Piasek, M. & Kostial, K. (2009) New therapeutic and experimental aspects of chelators as antidotes of metal toxicity. U: Atta-ur-Rahman & Reitz, A. (ur.) Frontiers in Medicinal Chemistry, Volume 4. Karachi, Bentham Science, str. 130-182.
@inbook{inbook, author = {Varnai, Veda Marija and Blanu\v{s}a, Maja and Piasek, Martina and Kostial, Krista}, editor = {Atta-ur-Rahman and Reitz, A.}, year = {2009}, pages = {130-182}, keywords = {chelating agents, BAL derivatives, carbodithioates, deferiprone, deferoxamine, deferasirox, D-penicillamine, polyaminopolycarboxylic acids, metal toxicity, age}, isbn = {90-77527-07-9}, title = {New therapeutic and experimental aspects of chelators as antidotes of metal toxicity}, keyword = {chelating agents, BAL derivatives, carbodithioates, deferiprone, deferoxamine, deferasirox, D-penicillamine, polyaminopolycarboxylic acids, metal toxicity, age}, publisher = {Bentham Science}, publisherplace = {Karachi} }
@inbook{inbook, author = {Varnai, Veda Marija and Blanu\v{s}a, Maja and Piasek, Martina and Kostial, Krista}, editor = {Atta-ur-Rahman and Reitz, A.}, year = {2009}, pages = {130-182}, keywords = {chelating agents, BAL derivatives, carbodithioates, deferiprone, deferoxamine, deferasirox, D-penicillamine, polyaminopolycarboxylic acids, metal toxicity, age}, isbn = {90-77527-07-9}, title = {New therapeutic and experimental aspects of chelators as antidotes of metal toxicity}, keyword = {chelating agents, BAL derivatives, carbodithioates, deferiprone, deferoxamine, deferasirox, D-penicillamine, polyaminopolycarboxylic acids, metal toxicity, age}, publisher = {Bentham Science}, publisherplace = {Karachi} }

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