Naslov
Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats

Autori
Grabarević, Željko ; Rotkvić, Ivica ; Sikirić, Predrag ; Seiwerth, Sven ; Džaja, Petar ; Perić, Josip ; Kos, Josip

Izvornik
Acta veterinaria Hungarica (0236-6290) 45 (1997), 1; 85-93

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Interaction; protective effect; dopaminergic system; cimetidine; dopamine agonists and antagonists; haemorrhagic gastric lesionsom
(Interaction; protective effect; dopaminergic system; cimetidine; dopamine agonists and antagonists; haemorrhagic gastric lesionso)

Sažetak
Pretreatment with dopamine agonists (bromocriptine 2.5, L-dopa 2.5, apomorphine 0.05 mg/kg i.p.) and a histamine H2 receptor antagonist (cimetidine 50.0 mg/kg i.p.) was found to greatly reduce the haomorrhagic gastric lesions induced by 15-min pylorus ligation in rats. On the other hand, pretreatment with dopamine antagonists (haloperidol 5.0, sulpiride 1.0, domperidone 5.0 mg/kg i.p.) significantly aggravated these lesions. Cimetidine markedly diminished the ulcerogenic effect of haloperidol but not that of domperidone, suggesting a brain-mediated site for the protective interaction of cimetidine and dopamine systems.

Izvorni jezik
Engleski

POVEZANOST RADA