Naslov
Radiation-induced chromosomal aberrations and haematological alterations in hospital workers

Autori
Rozgaj, Ružica ; Kašuba, Vilena ; Šentija, Karmela ; Prlić, Ivica

Izvornik
Occupational medicine-Oxford (0962-7480) 49 (1999), 6; 353-360

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
blood count; chromosome aberrations; ionizing radiation; occupational exposure

Sažetak
Long-term exposure to low doses of ionizing radiation may affect cells and tissues and result in various adverse health effects. The purpose of this study was to investigate weather chromosome aberrations and haematological alterations could be used as biomarkers of possible radiation injury in workers expposed to ionizing radiation. Groups totalling 323 medical professionals handling X-ray equipment and 160 control subjects were examined for incidence of chromosome aberrations and changes in leukocyte, lymphocyte and thrombocyte counts. The incidence of all types of chromosome aberrations was higher in the expposed groups than in controls, yet no significant difference was found between the exposed groups. A many-fold increase in chromosome aberration frequency in all exposed groups was not followed by a corresponding haematological depression. This suggests that chromosome aberrations are a significantly more sensitive indicator of changes caused by low doses of ionizing radiation than haematological alterations.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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