Naslov
Epilepsy and Cerebellar Atrophy Epilepsy and Cerebellar Atrophy
(Epilepsy and Cerebellar Atrophy)

Autori
Šepić Grahovac, Dubravka ; Cvitanović-Šojat, Ljerka ; Willheim, Ksenija ; Jurjević, Ante ; Papa, Jurica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstracts. Epilepsia Volumne 39 - Suppl.2 / - New York (NY) : Raven Press, 1998

Skup
Third European Congress of Epileptology

Mjesto i datum
Varšava, Poljska, 24.05.1998. - 28.05.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Epilepsy; Phenytoin; cerebellar atrophy

Sažetak
Adverse neurological effects of antiepileptic drugs to control seizures in epilepsy are well documented. Published literature on MRI of the brain has shown an association between cerebellar atrophy and the long-term antiepileptic drugs therapy in patients with epilepsy. We report a 20-year old patient with cerebellar ataxia, dysarthria and severe epilepsy. He had had normal development until age 7, when partial motor (right) and generalized tonic-clonic seizures had onset. EEG shoved diffuse paroxysmal changes, with multiple spike wave and spike discharges. Results of CT of the brain were normal, and results of tests for possible neurometabolic diseases showed average values. The past 13 years he has been treated with high doses of phenytoin, phenobarbital and valproate, with only partial success. He now has psychological and memory disturbances. Epileptic seizures have become rare this year, but cerebellar ataxia and dysarthria are present. MRI of the brain shows enormous cerebellar atrophy. Cerebellar atrophy is now considered a possible consequence of long-term treatment with antiepileptic drugs, especially phenytoin. In our patient, MR neuroimaging contributed to detection of etiological factors of neurological deficits.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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