Naslov
Immunohystochemical analysis of psoriatic lesions suggest active involvement of perforin molecule in the creation of psoriatic plaque

Autori
Kaštelan, Marija ; Prpić Massari, Larisa ; Simonić, Edita ; Zamolo, Gordana ; Čoklo, Miran ; Palle, Matko ; Gruber, Franjo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 13th Congress of the European Academy of Dermatology and Venereology ; u: Journal of the European Academy of Dermatology and Venereology 18 (2004) (S2) 1-633 ; / - , 2004

Skup
Congress of the European Academy of Dermatology and Venereology (13 ; 2004)

Mjesto i datum
Firenca, Italija, 17.11.2004. - 21.11.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
psoriasis; T cells; perforin

Sažetak
It seems that in psoriatic lesions proinflammatory cytokines released by activated CD4+ and CD8+ T cells generate keratinocyte proliferation and abnormal differentiation, a hallmark of psoriasis. However, the role of cytotoxic molecules, released by CD8+ T cells and NK cells, in the development of psoriatic lesions, is still not clear. Both, cytotoxic T cells and NK cells mediate cytotoxic reactions by two different mechanisms, perforin/granzyme and Fas/FasL pathway. In the present study, we analysed the distribution of perforin, T and NK cell subsets by immunohistochemistry. Skin biopsy specimens obtained from lesional psoriatic skin, non-lesional and healthy skin were analysed by immunohistochemistry. We observed strong expression of CD4+ and CD8+ T cells in the dermis and epidermis of psoriatic lesions but not in the non-lesional and healthy skin. Perforin-expressing cells were found with strong positivity mainly in the epidermis of psoriatic lesions in close contact with the damaged keratinocytes. Our study clearly showed that T lymphocytes might be responsible for inducing damage to keratinocytes by releasing cytolytic molecules as perforin itself.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
DOI: 10.1111/j.1468-3083.2004.01152.x

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