Naslov
Vascular endothelial growth factor in aqueous humor of patients with perforative eye injuries

Autori
Merlak, Maja ; Kovačević, Damir ; Balog, Tihomir ; Marotti, Tatjana ; Gržetić Lenac, Renata ; Romac, Ivana ; Dekaris, Iva

Izvornik
Collegium Antropologicum (0350-6134) 32 (2008), Suppl. 2; 33-37

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
vacular endothelial growth factor; aqueous humor; perforative eye injury

Sažetak
Considering that VEGF is the key factor for angiogenesis stimulation, we wanted to establish if VEGF level is increased in aqueous humor of patients with open globe eye injury. The study included 20 patients with open globe injury. During the surgery, aqueous humor samples were taken out and VEGF levels were measured by ELISA. VEGF levels were significantly higher in the aqueous humor of patients with open globe eye injury and uveitis, in patients with wound bigger than 2 mm and inpatients where from injury to surgery passed more than 4 hours. VEGF levels were also higher, but not significantly, in patients with intrabulbar foreign body. Considering that VEGF levels were significantly higher in patients with open globe eye injury with uveitis, wound larger than 2 mm and in patients where from injury to surgery passed more than 4 hours, anti VEGF therapy might have application in these conditions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA