Naslov
Plasma level of dipropylacetamide and dipropylacetic acid and effect of these drugs on 5-hydroxytryptamine metabolism in mouse brain

Autori
Whitton, P. S. ; Orešković, Darko ; Jernej, Branimir ; Radačić, Marko ; Plavšić, Franjo ; Bulat, Marin

Izvornik
Biomedicine & pharmacotherapy (0753-3322) 40 (1986), 5; 191-193

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dipropylacetamide ; plasma ; 5-HT ; 5-HIAA

Sažetak
After intraperitoneal application of the antiepileptics dipropylacetamide (DPM, 200 mg/kg) and dipropylacetic acid (DPA, 200 mg/kg) in mice their concentration in plasma and their effects on 5-hydroxytryptamine (5-HT) metabolism in the brain were followed during 360 minutes. Peak plasma level of DPA and DPM was observed at 30 minutes, but level of DPM was only about 25% that of DPA. Plasma content of both drugs declined to low levels by 360 minutes. Both drugs increased brain content of the 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA). After DPA application 5-HIAA level increased rapidly and had returned to control value by 360 minutes, while following DPM 5-HIAA increase was much more gradual and was more prolonged. Neither DPM nor DPA significantly altered brain 5-HT content. An apparent relationship between DPA plasma level and brain 5-HIAA content was observed while after DPM no association between plasma drug content and effect on cerebral 5-HT metabolism was seen.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA