Pregled bibliografske jedinice broj: 381470
Study of the lorazepam: cyclodextrin inclusion complexes using electrospray ionization mass spectrometry
Study of the lorazepam: cyclodextrin inclusion complexes using electrospray ionization mass spectrometry // Tetrahedron Letters, 42 (2001), 35; 6077-6082 (međunarodna recenzija, članak, znanstveni)
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Naslov
Study of the lorazepam: cyclodextrin inclusion complexes using electrospray ionization mass spectrometry
Autori
Kobetić, Renata ; Juršić, Branko S. ; Bonnette, Sidney ; Tsai, Jane T. -S. ; Salamone, Salvatore
Izvornik
Tetrahedron Letters (0040-4039) 42
(2001), 35;
6077-6082
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Lorazepam - ESI MS; Inclusion complexes; Cyclodextrin
Sažetak
As an example of drug– cyclodextrin interactions in aqueous media, the cyclodextrin complexation of lorazepam was studied by electrospray ionization mass spectroscopy (ES-MS). It was concluded that highly concentrated aqueous hydroxypropylcyclodextrins are more suited for the drug complexation and that the inclusion complex includes one molecule of the drug with two and three cyclodextrin molecules as well as two molecules of the drug with three molecules of hydroxypropylcyclodextrins. It was postulated that in the hydroxycyclodextrin cavity the drug molecule decomposes via the elimination of one molecule of formaldehyde.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
