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Pregled bibliografske jedinice broj: 380888

Effects of prometryne on apoptosis and necrosis in thymus, lymph node and spleen in mice

Đikić, Domagoj; Židovec-Lepej, Snježana; Remenar, Anica; Bendelja, Krešo; Benković, Vesna; Horvat-Kneževi, Anica; Brozović, Gordana; Oršolić, Nada
Effects of prometryne on apoptosis and necrosis in thymus, lymph node and spleen in mice // Environmental Toxicology and Pharmacology, 27 (2009), 2; 182-186 doi:10.1016/j.etap.2008.10.002 (međunarodna recenzija, članak, znanstveni)

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Naslov
Effects of prometryne on apoptosis and necrosis in thymus, lymph node and spleen in mice

Autori
Đikić, Domagoj ; Židovec-Lepej, Snježana ; Remenar, Anica ; Bendelja, Krešo ; Benković, Vesna ; Horvat-Kneževi, Anica ; Brozović, Gordana ; Oršolić, Nada

Izvornik
Environmental Toxicology and Pharmacology (1382-6689) 27 (2009), 2; 182-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
prometryne; immunotoxicity; CBA mice; Triazine; Flow cytometry

Sažetak
Prometryne is a methylthio-s-triazine herbicide. Significant traces are documented in environment, mainly waters, soil and plants used for nutrition. The aim of this study was to estimate prometryne immunotoxic properties through induction of apoptotic and/or necrotic changes in thymocytes, splenocytes and lymph node cells after repeated subchronical exposure. Three different doses of prometryne (185, 375, 555mgkg− 1) were applied per os every 48 h, over 28 days. Flow cytometry assay (annexinVFITC and PI) was conducted to record apoptotic and necrotic damage. In the spleen significant changes in the percentage of apoptotic cells were not detected between treated and control groups respectively. In thymus and lymph node, within the lowest dose group (185mgkg− 1), an increase in percentage of early apoptosis without any significant increase in necrosiswas detected.Medium (375mgkg− 1) aswell as high dose triggered increase in late apoptosis in lymph node while in thymus ; late apoptosis was increased only in animals exposed to the highest dose (555mgkg− 1). The highest applied dose, in thymus and lymph node respectively, caused a general decrease in percentage of vital cells in favour of marked increase of percentages of all types of dying cells (apoptotic, late apoptotic/early necrotic and necrotic). Prometryne caused disbalance in major organs of immune system, markedly lymph nodes and thymus, by induction of early apoptotic changes in dose/time specific manne

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)
143-1080116-0097 - Imunološka rekonstitucija i rezistencija na lijekove u HIV-bolesnika iz Hrvatske (Židovec-Lepej, Snježana, MZOS ) ( CroRIS)
219-0061194-2158 - Uloga lipidnih splavi i glikokonjugata u razvoju i regeneraciji živčanog sustava (Heffer, Marija, MZOS ) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Gordana Brozović (autor)

Avatar Url Domagoj Đikić (autor)

Avatar Url Vesna Benković (autor)

Avatar Url Krešo Bendelja (autor)

Avatar Url Anica Horvat Knežević (autor)

Avatar Url Vladimir Remenar (autor)

Avatar Url Nada Oršolić (autor)

Avatar Url Snježana Židovec-Lepej (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com ac.els-cdn.com dx.doi.org

Citiraj ovu publikaciju:

Đikić, Domagoj; Židovec-Lepej, Snježana; Remenar, Anica; Bendelja, Krešo; Benković, Vesna; Horvat-Kneževi, Anica; Brozović, Gordana; Oršolić, Nada
Effects of prometryne on apoptosis and necrosis in thymus, lymph node and spleen in mice // Environmental Toxicology and Pharmacology, 27 (2009), 2; 182-186 doi:10.1016/j.etap.2008.10.002 (međunarodna recenzija, članak, znanstveni)
Đikić, D., Židovec-Lepej, S., Remenar, A., Bendelja, K., Benković, V., Horvat-Kneževi, A., Brozović, G. & Oršolić, N. (2009) Effects of prometryne on apoptosis and necrosis in thymus, lymph node and spleen in mice. Environmental Toxicology and Pharmacology, 27 (2), 182-186 doi:10.1016/j.etap.2008.10.002.
@article{article, author = {\DJiki\'{c}, Domagoj and \v{Z}idovec-Lepej, Snje\v{z}ana and Remenar, Anica and Bendelja, Kre\v{s}o and Benkovi\'{c}, Vesna and Horvat-Kne\v{z}evi, Anica and Brozovi\'{c}, Gordana and Or\v{s}oli\'{c}, Nada}, year = {2009}, pages = {182-186}, DOI = {10.1016/j.etap.2008.10.002}, keywords = {prometryne, immunotoxicity, CBA mice, Triazine, Flow cytometry}, journal = {Environmental Toxicology and Pharmacology}, doi = {10.1016/j.etap.2008.10.002}, volume = {27}, number = {2}, issn = {1382-6689}, title = {Effects of prometryne on apoptosis and necrosis in thymus, lymph node and spleen in mice}, keyword = {prometryne, immunotoxicity, CBA mice, Triazine, Flow cytometry} }
@article{article, author = {\DJiki\'{c}, Domagoj and \v{Z}idovec-Lepej, Snje\v{z}ana and Remenar, Anica and Bendelja, Kre\v{s}o and Benkovi\'{c}, Vesna and Horvat-Kne\v{z}evi, Anica and Brozovi\'{c}, Gordana and Or\v{s}oli\'{c}, Nada}, year = {2009}, pages = {182-186}, DOI = {10.1016/j.etap.2008.10.002}, keywords = {prometryne, immunotoxicity, CBA mice, Triazine, Flow cytometry}, journal = {Environmental Toxicology and Pharmacology}, doi = {10.1016/j.etap.2008.10.002}, volume = {27}, number = {2}, issn = {1382-6689}, title = {Effects of prometryne on apoptosis and necrosis in thymus, lymph node and spleen in mice}, keyword = {prometryne, immunotoxicity, CBA mice, Triazine, Flow cytometry} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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  • MEDLINE

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