Naslov
Comparison on platelet acttivities in IDDM patients on conventional therapy and insulin pump treatment

Autori
Turk, Zdenka ; Flego, Iris ; Kerum, Gorazd ; Turk, Nikša ; Metelko, Željko

Izvornik
Diabetologia Croatica (0351-0042) 25 (1996), 4; 165-171

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Insulin pump; platelet aggregation; thromboxane B2 synthesis

Sažetak
The effect of metabolic control on platelet activities was studied in 11 IDDM patients during six months of continuous insulin infusion (CSII) treatment in comparison to three months of conventional therapy. Patients included in the study were free of microvascular disease. The effectiveness of intensive therapy in lowering blood glucose are reflected in a significant HbA1c reduction (8.26?0.56 vs 6.16?0.14% , p<0.002). The accompanying improvement in ex vivo aggregation of platelets in response to two agonists was only observed with the achievement of glycemia control (ADP: 20.84?1.46 vs 14.84?0.95%, p<0.001 ; arachidonic acid: 22.04?1.35 vs 16.0?0.99%, p<0.01). The synthesis of thromboxane-B2, as a response to arachidonate, was lower during the CSII period (TxB2:415?16 vs 382?14 ?g/lx106 platelets), with statistical significance p<0.001.In all patients the change in proaggregatory thromboxane B2 correlated with the HbA1c level: r=0.62, p<0.02. Along with normal fibrinogen level pre- and post-CSII (346ą24 vs 307ą17 g/l) we found a significant association between fibrinogen and ADP-induced aggregation in pretreatment period (r=0.63, p?0.03), but during CSII treatment this association was not observed. In the present study plasma fibrinogen significantly correlated with the level of glycemia control (r=0.61, p?0.002). Results suggested that intensive insulin treatment reduced platelet aggregation and release reactions in patients without microvascular disease when strict glycemia control was maintained and indicated that changes in platelet aggregation could directly result from changes in plasma glucose concentrations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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