Pregled bibliografske jedinice broj: 380348
Nm23-H1 promotes adhesion of CAL 27 cells in vitro
Nm23-H1 promotes adhesion of CAL 27 cells in vitro // Molecular carcinogenesis, 48 (2009), 9; 779-789 doi:10.1002/mc.20536 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 380348 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Nm23-H1 promotes adhesion of CAL 27 cells in vitro
Autori
Bago, Ružica ; Pavelić, Jasminka ; Maravić Vlahoviček, Gordana ; Herak Bosnar, Maja
Izvornik
Molecular carcinogenesis (0899-1987) 48
(2009), 9;
779-789
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
adhesion ; CAL 27 ; migration ; nm23 ; OSCC
Sažetak
Nm23-H1 was found to diminish metastatic potential of carcinoma cell lines and therefore was placed in the group of metastatic suppressor genes. Its protein product has a function of a nucleosid-diphosphate kinase (NDPK) as well as protein kinase and nuclease. Though it was found that nm23-H1 is involved in many cellular processes, it is still not known how it promotes metastatic suppressor activity. Since the process of metastasis is dependent on adhesion properties of cells, the goal of our work was to describe the adhesion properties of CAL 27 cells (oral squamous cell carcinoma of the tongue) overexpressing FLAG/nm23-H1. In our experiments, cells overexpressing nm23-H1 show reduced migratory and invasive potential. Additionally, cells overexpressing Nm23-H1 adhere stronger on substrates (collagen IV and fibronectin) and show more spread morphology than the control cells. Results obtained by EGF induction of migration revealed that the adhesion strength predetermined cell response to chemoattractant and that Nm23-H1, in this cell type, does not interfere with, EGF induced, Ras signaling pathway. These data contribute to the overall knowledge about nm23-H1 and its role in cell adhesion, migration and invasion, especially in oral squamous cell carcinoma.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
098-0982464-2513 - Uloga gena nm23 u karcinomu pločastog epitela usne šupljine (Herak-Bosnar, Maja, MZOS ) ( CroRIS)
101-0982464-2277 - Molekularno profiliranje metastazirajućeg tumora dojke (Dekaris, Dragan, MZOS ) ( CroRIS)
098-0982464-2394 - Gensko liječenje tumora djelovanjem na molekule imunološkog sustava (Pavelić, Jasminka, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb
Profili:
Maja Herak Bosnar
(autor)
Ružica Bago
(autor)
Gordana Maravić Vlahoviček
(autor)
Jasminka Pavelić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE