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Pregled bibliografske jedinice broj: 379982

Effect of 3, 4-Ethylenedioxy- Extension of Thiophene Core on the DNA/RNA Binding Properties and Biological Activity of Bis-Benzimidazole Amidines

Stolić, Ivana; Mišković, Katarina; Magdaleno, Anahi; Silber, Ariel Mariano; Piantanida, Ivo; Bajić, Miroslav; Glavaš-Obrovac, Ljubica
Effect of 3, 4-Ethylenedioxy- Extension of Thiophene Core on the DNA/RNA Binding Properties and Biological Activity of Bis-Benzimidazole Amidines // Bioorganic & medicinal chemistry letters, 17 (2009), 6; 2544-2554 doi:10.1016/j.bmc.2009.01.071 (međunarodna recenzija, članak, znanstveni)

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Naslov
Effect of 3, 4-Ethylenedioxy- Extension of Thiophene Core on the DNA/RNA Binding Properties and Biological Activity of Bis-Benzimidazole Amidines

Autori
Stolić, Ivana ; Mišković, Katarina ; Magdaleno, Anahi ; Silber, Ariel Mariano ; Piantanida, Ivo ; Bajić, Miroslav ; Glavaš-Obrovac, Ljubica

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 17 (2009), 6; 2544-2554

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
benzimidazole amidine ; DNA/RNA binding ; antiproliferative activity ; antiparasitic activity

Sažetak
Novel bisbenzimidazoles (4– 6), characterized by 3, 4-ethylenedioxy- extension of thiophene core, revealed pronounced affinity and strong thermal stabilization effect toward ds-DNA. They interact within ds-DNA grooves as dimmers or even oligomers and agglomerate along ds-RNA. Compounds 4– 6 have shown moderate to strong antiproliferative effect toward panel of eight carcinoma cell lines. Compound 5 displayed the best inhibitory potential and in equitoxic concentration (IC50 = 1 x 10– 6 M) induced accumulation of cells in G2/M phase after 48 h of incubation. Fluorescence microscopy showed that 5 entered into live HeLa cells within 30 min, but did not accumulate in nuclei even after 2.5 h. Compound 5 inhibited the growth of T. cruzi epimastigotes (IC50 = 4.3 x 10– 6 M).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
053-0982914-2965 - Dizajn i sinteza bisamidina sa protutumorskim djelovanjem (Bajić, Miroslav, MZOS ) ( CroRIS)
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Glavaš Obrovac, Ljubica, MZOS ) ( CroRIS)
219-0982914-2179 - Uloga malih zaštitinih TFF proteina u zdravlju i bolesti (Belovari, Tatjana, MZOS ) ( CroRIS)

Ustanove:
Veterinarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Osijek

Profili:

Avatar Url Ivo Piantanida (autor)

Avatar Url Miroslav Bajić (autor)

Avatar Url Katarina Mišković Špoljarić (autor)

Avatar Url Ljubica Glavaš Obrovac (autor)

Avatar Url Ivana Stolić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Stolić, Ivana; Mišković, Katarina; Magdaleno, Anahi; Silber, Ariel Mariano; Piantanida, Ivo; Bajić, Miroslav; Glavaš-Obrovac, Ljubica
Effect of 3, 4-Ethylenedioxy- Extension of Thiophene Core on the DNA/RNA Binding Properties and Biological Activity of Bis-Benzimidazole Amidines // Bioorganic & medicinal chemistry letters, 17 (2009), 6; 2544-2554 doi:10.1016/j.bmc.2009.01.071 (međunarodna recenzija, članak, znanstveni)
Stolić, I., Mišković, K., Magdaleno, A., Silber, A., Piantanida, I., Bajić, M. & Glavaš-Obrovac, L. (2009) Effect of 3, 4-Ethylenedioxy- Extension of Thiophene Core on the DNA/RNA Binding Properties and Biological Activity of Bis-Benzimidazole Amidines. Bioorganic & medicinal chemistry letters, 17 (6), 2544-2554 doi:10.1016/j.bmc.2009.01.071.
@article{article, author = {Stoli\'{c}, Ivana and Mi\v{s}kovi\'{c}, Katarina and Magdaleno, Anahi and Silber, Ariel Mariano and Piantanida, Ivo and Baji\'{c}, Miroslav and Glava\v{s}-Obrovac, Ljubica}, year = {2009}, pages = {2544-2554}, DOI = {10.1016/j.bmc.2009.01.071}, keywords = {benzimidazole amidine, DNA/RNA binding, antiproliferative activity, antiparasitic activity}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmc.2009.01.071}, volume = {17}, number = {6}, issn = {0960-894X}, title = {Effect of 3, 4-Ethylenedioxy- Extension of Thiophene Core on the DNA/RNA Binding Properties and Biological Activity of Bis-Benzimidazole Amidines}, keyword = {benzimidazole amidine, DNA/RNA binding, antiproliferative activity, antiparasitic activity} }
@article{article, author = {Stoli\'{c}, Ivana and Mi\v{s}kovi\'{c}, Katarina and Magdaleno, Anahi and Silber, Ariel Mariano and Piantanida, Ivo and Baji\'{c}, Miroslav and Glava\v{s}-Obrovac, Ljubica}, year = {2009}, pages = {2544-2554}, DOI = {10.1016/j.bmc.2009.01.071}, keywords = {benzimidazole amidine, DNA/RNA binding, antiproliferative activity, antiparasitic activity}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmc.2009.01.071}, volume = {17}, number = {6}, issn = {0960-894X}, title = {Effect of 3, 4-Ethylenedioxy- Extension of Thiophene Core on the DNA/RNA Binding Properties and Biological Activity of Bis-Benzimidazole Amidines}, keyword = {benzimidazole amidine, DNA/RNA binding, antiproliferative activity, antiparasitic activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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