Naslov
Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population

Autori
Boraska, Vesna ; Škrabić, Veselin ; Čikeš Čulić, Vedrana ; Bečić, Kristijan ; Kapitanović, Sanja ; Zemunik, Tatijana

Izvornik
Biological Research (0716-9760) 41 (2008), 2; 157-163

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Type 1 diabetes; tmor necrosis factor gene (TNF); polymorphism; genetic epidemiology; Croatia

Sažetak
Type 1 diabetes mellitus (TIDM) is an autoimmune disease characterized by the destruction of pancreatic beta cells. Tumor necrosis factor (TNF) is a pleotropic cytokine with potent immunomodulatory and inflammatory activity. Association studies of TNF polymorphisms and type 1 diabetes (TIDM) frequently demonstrated TNF involvement with TIDM. Although TNF may play an important role in the pathogenesis of TIDM, the genetic association of TNF región with the disease has not been conclusive because of the strong linkage disequilibrium with HLA genes. In this study, we examined two TNF promoter variants (rs 1800629 at position -308, and rs361525 at position -238) for TIDM association in 233 patients and 144 controls from the population of South Croatia. A higher frequency of TNF -308 A alíele and also, a more frequent specific -308A -238G haplotype in TIDM patients were observed with a limited significance. However, we did not find strong evidence of association of TNF promoter polymorphisms with TIDM. In order to elucidate the trae contribution of TNF to TIDM susceptibility in our population, more comprehensive studies with HLA adjustment in a larger sample are required.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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