Naslov
Effect of cisplatin and 6-bromo-6-deoxy-L-ascorbic acid on some biochemical and functional parameters in mice

Autori
Šverko, Višnja ; Radačić, Marko ; Gavella, Mirjana ; Lipovac, Vaskrsenija ; Ljubenkov, Ivan ; Eckert-Maksić, Mirjana

Izvornik
Toxicology (0300-483X) 137 (1999), 1; 23-24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cis-dichlorodiamineplatinum; 6-bromo-6-deoxy-L-ascorbic acid; lipid peroxidation; sialic acid; lysosomes

Sažetak
The results of the present study demonstrate that 6-bromo-6-deoxy-L-ascorbic acid (6-BrAA), an antioxidative derivative of ascorbic acid is capable of lowering the toxicity of cisplatin, cis-diaminedichloroplatinum (cis-DDP), an anticancerogenic drug. The biological aspects and pharmacological significance of combined treatment of these two substances were investigated in a mouse model. The results indicate that the effectiveness of 6-BrAA no biological response(s) is strongly dependent on the dose of cis-DDP. Injection of 10 mg/kg body weight (bw) of cis-DDP following pretreatment with 6-BrAA (480 mg/kg bw) enhances the tissue-protecting effect of 6-BrAA and reduce, to some extent, the ensuing nephro-, liver and spleen toxicity. On the other hand, 6-BrAA in animals treated with higher dose of cis-DDP (15 mg/kg bw) leads to exacerbation of the toxic cis-DDP effect and concurrent loss of the protective potential of 6-BrAA with respect to tissue damage. The exact mechanism(s) of 6-BrAA protection and exarcebation of the toxic cis-DDP effect is unclear, although scavenging or generating of free radicals may play important role. The results obtained may be of importance in planning the rational use of cis-DDP and 6-BrAA administration potential treatment of cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA