Naslov
Preparation of hybrid organic/inorganic materials for drug delivery

Autori
Kralj, Damir ; Ukrainczyk, Marko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
New Materials in Industry & Medicine, Book of Abstracts / Žarković, Neven - Zagreb, 2008, 32-32

Skup
Workshop on New Materials in Industry & Medicine

Mjesto i datum
Zagreb, Hrvatska, 25.11.2008. - 26.11.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hybrid organic/inorganic materials; drug delivery systems

Sažetak
Hybrid organic/inorganic materials are group of compounds that can be used for a controlled introduce and/or release of active organic substances in living organisms and tissues. Two groups of hybrid materials (calcium carbonate (CaCO3) or layered double hydroxide(s) (Mg(1-x)M3+x(OH)2(Am-)x/m• nH2O)), into which model organic molecules (anti-inflammatory drugs) are absorbed/intercalated, will be prepared by precipitation from aqueous solutions. The chemical-physical properties of such materials (morphology, specific surface area, porosity, chemical and mineralogical composition, kinetics and extent of release of organic molecules and particularly particle size) will be correlated with the preparation conditions. However, in vitro testing under conditions similar to physiological will enable an estimation of the importance of a particular incorporation mechanism (absorption or intercalation) in the overall efficiency of the controlled release. Namely, in distinction from the porous calcium carbonates, in which the organic component is absorbed in the pores of carrier or adsorbed at the particle surface, in the case of layered double hydroxides, the organic molecules are in the form of anions and are bound electrostatically to the mineral layer, so that their release is a consequence of ionic exchange with counter ions from the surrounding media. Subsequent treatment of surfaces of nanosized hybrid particles with appropriate compounds (e.g. polyethylene glycol) will be also done in order to test the biocompatibility of such materials and their potential to avoid phagocytosis by the reticuloendothelial system or cells.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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