Naslov
Expression of renal transporters in experimental syngenic and allogenic transplants: Effects of Cyclosporine A

Autori
Brzica, Hrvoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Göttinger Transporttage 2008

Mjesto i datum
Göttingen, Njemačka, 22.11.2008. - 23.11.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Kidney; transplatation; syngenic; allogenic

Sažetak
In transplantation of various organs it is very important to have genetic congruency. According to the donor– recipient relationship, transplantations can be: xenogenic – among different species, allogenic – within the same species but different genetic background, syngenic – within the same species of the same genetic background. In humans, after renal transplantation, patients often develop various degrees of tubular disfunction, such as increased water and potassium excretion and sodium retention. Cellular mechanisms responsible for these dysfunctions are poorly known. Previous studies in experimentaly transplanted allogenic kidneys in rats reported on downregulation of NHE3 and AQP2 proteins 2-4 days following operation. The aim of the present study was to examine the expression of various transport proteins, and an effect of immunosupressive drug CsA in kidneys following syngenic and allogenic transplantations. AQP2, SGLT2 and OCT1 were only slightly downregulated in transplanted syngenic kidney and strongly downregulated in transplanted allogenic kidney. Transplantation did not affect the expression of OCT2, AQP1, SGLT1 and OAT1. NHE3 is the only protein that showed downregulation in the cortex and upregulation in the outer stripe. Allogenic transplantation exhibited marked signs of rejection, showing damaged proximal tubules and massive infiltration of inflammatory cells in peritubular space. These phenomena were most extensive in the cortex, and were ameliorated following CsA treatment. In the same time, the expression of transporters was recovered to the control levels.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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