Naslov
Correlation between frequency of micronuclei and status of folate and vitamin B12 in operating theatre staff

Autori
Rozgaj, Ružica ; Kašuba, Vilena ; Milić, Mirta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 45th Congress of the European Societies of Toxicology (Eurotox 2008) and NewGeneris Workshop ; u: Toxicology Letters 180 (2008) (S1) S1-S246 ; R48 / Tsatsakis, Aristidis M. ; Liesivuori, Jyrki - , 2008, S74-S74

Skup
Congress of the European Societies of Toxicology (45 ; 2008)

Mjesto i datum
Rodos, Grčka, 05.10.2008. - 08.10.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
micronuclei frequency; operating theatre staff; folate; vitamin B12

Sažetak
Genotoxic effects of inhalation anaesthetics have already been described. Of special concern is the exposure of medical staff in operating theatre, which is chronically exposed to low doses of different anaesthetics. In this study a group of medical workers of different professions, exposed to anaesthetics, mostly sevoflurane, isoflurane and nitrous oxide, and matched, non- exposed control group was investigated for the frequency of micronuclei (MN). The aim of this study was to investigate whether a status of folic acid (FA) and vitamin B12, as known factors of genome stability, influence a level of genome damage in studied groups. Frequency of MN elevate (p<0.05) in exposed group as compared to control (14.29 vs. 8.77). B12 concentrations were higher in control group (577.83 mg/L vs. 463.53 mg/L). Control group also had two times higher values of FA (10.15 mg/L vs. 5.89mg/L). Age, duration of exposure or smoking did not show significant influence to a MN frequency in exposed group. Further investigations will include a larger group of both exposed and control subjects to ensure more reliable results.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

Napomena
Workshop 14: Exogenous and Endogenous Background Exposures to Carcinogens and Regulatory Consequences ; Poster Presentations S32-S89, P3: Risk Assessment ; doi:10.1016/j.toxlet.2008.06.587

POVEZANOST RADA