Naslov
Synthesis and crystal structures of two isomeric nitro-alpha-resorcylic acids

Autori
Čorić, Ilija ; Milić, Dalibor ; Matković-Čalogović, Dubravka ; Tomašković, Linda

Izvornik
Structural Chemistry (1040-0400) 20 (2009), 1; 73-80

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
3; 5-dihydroxy-2-nitrobenzoic acid; 3; 5-dihydroxy-4-nitrobenzoic acid; alpha-resorcylic acid; X-ray structure; aromatic nitration

Sažetak
Nitration of α -resorcylic acid (3, 5-dihydroxybenzoic acid) to 3, 5-dihydroxy-2-nitrobenzoic acid (1) and 3, 5-dihydroxy-4-nitrobenzoic acid (2), their separation, and crystallization is described. Crystal structures of 1, 1 · 3H2O, and 2 were determined by X-ray single-crystal diffraction analysis and compared with DFT-calculated structures. An intramolecular hydrogen bond between the nitro group and o-hydroxyl group(s) occurs in all investigated structures. Intermolecular hydrogen bonds and π · · · π stacking interactions determine the molecular packing. Additionally, N· · · O interactions have a crucial role in arrangement of the molecules in the crystal structures of 1 and 2. DFT calculations in the gas phase and in the solution reveal that minor product 2 is a more stable regioisomer than 1, the major product in the nitration reaction.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA