Pregled bibliografske jedinice broj: 375208
Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase
Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase
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Naslov
Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase
Autori
Hauer, Bernhard ; Janssen, B. Dick ; Majerić Elenkov, Maja
Nositelj prava
BASF AG, Ludwigshafen, DE
Sažetak
The present invention provides a process for the production of optically enriched oxazolidinones from cyanide and epoxide, by means of kinetic resolution catalysed by halohydrin dehalogenases. Particular good results have been obtaind by using a halohydrin dehalogenase from Agrobacterium radiobacter strain AD1. 5-substituted oxazolidinones were obtained in high yield (47%) and with high enentiopurity (98% ee).
Izvorni jezik
Engleski
Znanstvena područja
Kemija
