Pregled bibliografske jedinice broj: 374452
Dilations of middle cerebral arteries of salt-sensitive rats are restored by receiving portions of Brown-Norway Chromosome 13 containing BN renin gene
Dilations of middle cerebral arteries of salt-sensitive rats are restored by receiving portions of Brown-Norway Chromosome 13 containing BN renin gene // Proceedings of the 25th Conference of the European Society for Microcirculation / Akos Koller, Akos (ur.).
Bolonja, 2008. str. 51-56 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
CROSBI ID: 374452 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Dilations of middle cerebral arteries of salt-sensitive rats are restored by receiving portions of Brown-Norway Chromosome 13 containing BN renin gene
Autori
Drenjančević-Perić, Ines ; Durand, Mathew ; MOreno-Quinn, Carol ; Lombard, Julian H
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Proceedings of the 25th Conference of the European Society for Microcirculation
/ Akos Koller, Akos - Bolonja, 2008, 51-56
ISBN
978-88-7587-461-2
Skup
Conference of the European Society for Microcirculation (25 ; 2008)
Mjesto i datum
Budimpešta, Mađarska, 26.08.2008. - 29.08.2008
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
microcirculation; renin gene; consomic rats
Sažetak
Previous studies have shown that introgression of Brown Norway (BN) chromosome 13 containing the BN allele of the renin gene into the Dahl saltsensitive (SS) genetic background (SS.13BN consomic rats) not only restores normal regulation of plasma renin activity and circulating ANG II levels, but also restores vasodilator responses to low PO2 and acetylcholine (ACh). Although SS.13BN rats are 98% identical to SS rats genetically, chromosome 13 contains a number of genes in addition to the renin allele that could affect vascular relaxation mechanisms. The goal of the present study was to evaluate the dilator responses of middle cerebral arteries (MCA) to low PO-2, ACh, and the stable prostacyclin analogue iloprost in SS-derived congenic rat strains receiving smaller portions of BN chromosome 13 surrounding the renin allele. This study utilized congenic strains 7, 8, and 9 containing successively smaller portions of BN chromosome 13, but all carrying the BN renin allele. All rats were fed low salt (0.4% NaCl) diet. MCA of SS rats failed to dilate, whereas MCA of all 3 congenic strains dilated in response to low PO2, ACh, and iloprost, supporting the hypothesis that replacement of the SS renin gene with the BN renin allele rescues vascular relaxation that is lost in SS rats.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
219-2160133-2034 - Djelovanje kisika na vaskularnu funkciju u zdravlju i bolesti (Drenjančević, Ines, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Osijek
Profili:
Ines Drenjančević
(autor)
