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Pregled bibliografske jedinice broj: 372682

Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder

Hercigonja Novković, Vesna; Rudan, Vlasta; Pivac, Nela; Nedić, Gordana; Muck-Šeler, Dorotea
Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder // Neuropsychobiology, 59 (2009), 1; 17-22 doi:: 10.1159/000202825 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 372682 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder

Autori
Hercigonja Novković, Vesna ; Rudan, Vlasta ; Pivac, Nela ; Nedić, Gordana ; Muck-Šeler, Dorotea

Izvornik
Neuropsychobiology (0302-282X) 59 (2009), 1; 17-22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
attention-deficit/hyperactivity disorder; children; platelet serotonin; impulsivity

Sažetak
Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric disorder highly prevalent in children. The neurobiology of ADHD is still not clear, but is assumed to be related to disturbances in catecholaminergic and serotonergic (5-hydroxytryptamine, 5-HT) systems. Peripheral indices of central 5-HT function were shown by recent studies to be lower, unaltered, or increased in ADHD. The study determined platelet 5-HT concentration in 84 medication-free 9 years-old (range 4-14 years) boys and girls with DSM-IV diagnosis of ADHD, subdivided according to the different symptoms (inattention, hyperactivity, and impulsivity) and clinical ADHD subtypes (predominantly hyperactive, predominantly inattentive, and combined subtype), and in 30 age and sex-matched healthy controls. Children with ADHD had similar platelet 5-HT concentrations as control children. Platelet 5-HT concentration did not differ between boys and girls, and between children with a hyperactive, inattentive, and combined subtype of ADHD. In children with ADHD there was a significant positive correlation between platelet 5-HT concentration and impulsive symptoms, but not with symptoms of inattention or hyperactivity. Platelet 5-HT concentration was significantly higher in impulsive compared to non-impulsive children with ADHD. The data provide preliminary evidence that increased platelet 5-HT concentration in impulsive children with ADHD might be a trait marker, predictive of impulsivity in ADHD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)
108-1962766-0260 - Prediktivna vrijednost procjene emocionalnih i ponašajnih problema u mladih (Rudan, Vlasta, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Vlasta Rudan (autor)

Avatar Url Gordana Nedić Erjavec (autor)

Avatar Url Vesna Hercigonja (autor)

Avatar Url Dorotea Muck-Šeler (autor)

Avatar Url VESNA HERCIGONJA NOVKOVIĆ (autor)

Avatar Url Nela Pivac (autor)

Poveznice na cjeloviti tekst rada:

doi content.karger.com content.karger.com

Citiraj ovu publikaciju:

Hercigonja Novković, Vesna; Rudan, Vlasta; Pivac, Nela; Nedić, Gordana; Muck-Šeler, Dorotea
Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder // Neuropsychobiology, 59 (2009), 1; 17-22 doi:: 10.1159/000202825 (međunarodna recenzija, članak, znanstveni)
Hercigonja Novković, V., Rudan, V., Pivac, N., Nedić, G. & Muck-Šeler, D. (2009) Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder. Neuropsychobiology, 59 (1), 17-22 doi:: 10.1159/000202825.
@article{article, author = {Hercigonja Novkovi\'{c}, Vesna and Rudan, Vlasta and Pivac, Nela and Nedi\'{c}, Gordana and Muck-\v{S}eler, Dorotea}, year = {2009}, pages = {17-22}, DOI = {DOI: 10.1159/000202825}, keywords = {attention-deficit/hyperactivity disorder, children, platelet serotonin, impulsivity}, journal = {Neuropsychobiology}, doi = {DOI: 10.1159/000202825}, volume = {59}, number = {1}, issn = {0302-282X}, title = {Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder}, keyword = {attention-deficit/hyperactivity disorder, children, platelet serotonin, impulsivity} }
@article{article, author = {Hercigonja Novkovi\'{c}, Vesna and Rudan, Vlasta and Pivac, Nela and Nedi\'{c}, Gordana and Muck-\v{S}eler, Dorotea}, year = {2009}, pages = {17-22}, DOI = {DOI: 10.1159/000202825}, keywords = {attention-deficit/hyperactivity disorder, children, platelet serotonin, impulsivity}, journal = {Neuropsychobiology}, doi = {DOI: 10.1159/000202825}, volume = {59}, number = {1}, issn = {0302-282X}, title = {Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder}, keyword = {attention-deficit/hyperactivity disorder, children, platelet serotonin, impulsivity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • BIOSIS Previews (Biological Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE

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