Naslov
Ethnic differences in the brain-derived neurotrophic factor Val66Met polymorphism in Croatian and Korean healthy subjects

Autori
Pivac, Nela ; Kim, Byungsu ; Nedić, Gordana ; Joo, Yeon Ho ; Kozarić-Kovačić, Dragica ; Hong, Jin Pyo ; Muck-Šeler, Dorotea

Izvornik
Croatian medical journal (0353-9504) 50 (2009), 1; 43-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Asian subjects; BDNF val66met; Caucasians; Croatians; ethnic differences; healthy individuals; Koreans

Sažetak
Aim was to compare in a multi-centric study the frequency of alleles and genotypes in BDNF val66met polymorphism in ethnically homogenous Caucasian (from Croatia) and ethnically homogenous Asian (from South Korea) healthy subjects, as inter-population differences in BDNF val66met may be responsible for the divergent findings in genetic and association studies. BDNF val66met was genotyped in 800 (556 Croatian and 244 Korean) healthy subjects. Frequencies of alleles and genotypes were evaluated using a chi-square test. The frequencies for genotypes ( 2=114.69 ; df=2 ; p<0.001) and alleles (χ 2 =120.07 ; df=1 ; p<0.001) between Korean and Croatian individuals differed significantly, due to significantly lower (46.3% and 19.5%, p<0.001) frequency of "Met" allele, and significantly higher (53.7% and 80.5%, p<0.001) frequency of "Val" allele in Croatian subjects compared to Korean subjects. The study found significant ethnic differences in BDNF val66met polymorphism. Asian subjects had the most frequent "Met/Val" genotype and similar distribution of "Met" and "Val" alleles. In contrast, Caucasian subjects had the most frequent "Met/Val" genotype and different distribution of "Met" and "Val" alleles. These ethnic differences require matching subjects for ethnicity in pharmacogenetic studies, and in the studies investigating genetic variations in neuropsychiatric disorders.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA