Pregled bibliografske jedinice broj: 369209
Life-threatening Valproate Overdose Successfully Treated with Haemodialysis
Life-threatening Valproate Overdose Successfully Treated with Haemodialysis // Arhiv za higijenu rada i toksikologiju, 59 (2008), 4; 295-298 doi:10.2478/10004-1254-59-2008-1884 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 369209 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Life-threatening Valproate Overdose Successfully Treated with Haemodialysis
Autori
Meštrović, Julije ; Filipović, Tomislav ; Polić, Branka ; Stričević, Luka ; Omazić, Ante ; Kuzmanić-Šamija, Radenka ; Markić, Joško
Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 59
(2008), 4;
295-298
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
central nervous system depressants; intensive care; thrombocytopenia; toxicity
Sažetak
Valproate (VPA) poisoning is an increasing clinical problem. The most common finding in VPA overdose is the depression of the central nervous system, which may progress to coma and death. This type of poisoning is difficult to treat, as no antidote exists. This report describes a case with a 16-year-old girl who poisoned herself with valproate. Initial treatment included naloxone, but she did not respond. She became comatose, with serum VPA concentration of 1320 µ ; ; g mL-1. Three sessions of haemodialysis were performed, effectively eliminating VPA and decreasing the serum concentration. The patient regained consciousness and fully recovered. To our knowledge, this is the highest serum VPA concentration reported by now in children aged 16 or less. Haemodialysis has proved to be the treatment of choice for life-threatening acute VPA overdose in children.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
216-0000000-3391 - Djeca s posebnim zdravstvenim potrebama (Meštrović, Julije, MZOS ) ( CroRIS)
Ustanove:
KBC Split,
Medicinski fakultet, Split
Profili:
Radenka Kuzmanić-Šamija
(autor)
Julije Meštrović
(autor)
Tomislav Filipović
(autor)
Joško Markić
(autor)
Branka Polić
(autor)
Mislav Ante Omazić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Analytical Abstracts
- BIOSIS Previews (Biological Abstracts)
- CANCERLIT
- CA Search (Chemical Abstracts)
- MEDLINE
- Pollution Abstracts
- Water Resources Abstracts