Naslov
Fenoprofen and ketoprofen amides as potential antitumor agents

Autori
Marjanović, Marko ; Zorc, Branka ; Pejnović, Lana ; Zovko, Marijana ; Kralj, Marijeta

Izvornik
Chemical biology & drug design (1747-0277) 69 (2007), 3; 222-226

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antiproliferative effect ; apoptosis ; cell cycle arrest ; fenoprofen ; fenoprofenamides ; human tumor cell lines ; ketoprofen ; ketoprofenamides ; lipophilicity

Sažetak
Following numerous experimental observations that various non-steroidal anti-inflammatory drugs have antitumor potentials, a series of fenoprofenamides (1a– g) and ketoprofenamides (2a– c) was tested on proliferation of different human tumor cell lines and normal human fibroblasts in vitro. Fenoprofen and ketoprofen showed modest antiproliferative activity, whereas the growth inhibitory activity of the tested amides clearly demonstrates that the substituents linked by an amide bond are essential for the significantly stronger cytostatic activity, probably because of a greater lipophilicity and/or better cell uptake. Additionally, it was shown that the most active derivatives (1d and 2a) induced cell cycle arrest at the G1 phase, as well as apoptosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA