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Pregled bibliografske jedinice broj: 368059

Serum platelet-activating factor acetylhydrolase (PAF-AH) activity and C-reactive protein (CRP) concentration in pigs after splenectomy and autologous spleen transplantation

Turk, Romana; Vnuk, Dražen; Svetina, Ante; Flegar-Meštrić, Zlata; Gereš, Darko; Robić, Mirna; Juretić, Dubravka
Serum platelet-activating factor acetylhydrolase (PAF-AH) activity and C-reactive protein (CRP) concentration in pigs after splenectomy and autologous spleen transplantation // 13th ISACP, 10th ESVCP, 8th AECCP & 7th APP Congress : APP Symposium abstracts
Barcelona, Španjolska, 2008. str. 2-2 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 368059 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Serum platelet-activating factor acetylhydrolase (PAF-AH) activity and C-reactive protein (CRP) concentration in pigs after splenectomy and autologous spleen transplantation

Autori
Turk, Romana ; Vnuk, Dražen ; Svetina, Ante ; Flegar-Meštrić, Zlata ; Gereš, Darko ; Robić, Mirna ; Juretić, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th ISACP, 10th ESVCP, 8th AECCP & 7th APP Congress : APP Symposium abstracts / - , 2008, 2-2

Skup
13th ISACP, 10th ESVCP, 8th AECCP & 7th APP Congress

Mjesto i datum
Barcelona, Španjolska, 30.09.2008. - 03.10.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PAF-AH; CRP; acute phase response; pigs; splenectomy; spleen autotransplantation

Sažetak
The spleen is an important lymphatic organ with a major role in many specific and unspecific immune reactions. Autologous splenic transplantation appears to be the only possible spleen-saving technique after total splenectomy. The aim of this study was to evaluate the inflammatory response after total splenectomy and spleen autotransplantation in pigs by measuring serum platelet-activating factor acetylhydrolase activity and C-reactive protein concentration. Nineteen piglets were randomly divided into three groups: sham-operated with spleens intact (n=6), total splenectomy (n=6), and splenic autotransplantation (n=7) with small fragments of the spleen autotransplanted into the greater omentum. The blood samples were taken just before surgery and on day 1st, 5th, 12th, 26th and 40th postoperatively. PAF-AH activity and CRP concentration were assayed in the sera. PAF-AH activity was significantly increased (P<0.05) on day 5th after splenectomy and on day 26th postoperatively in sham-operated pigs while there was no significant increase after spleen autotransplantation. CRP was significantly increased after surgery in all experimental groups. Conclusion: Results demonstrate increased PAF-AH activity in pigs after splenectomy and sham-operation as well as time-course increase of CRP concentration in all groups after surgery suggesting post-injury inflammatory response due to surgical trauma.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina, Farmacija



POVEZANOST RADA

Projekti:
044-0061245-0551 - Novi biokemijski biljezi ateroskleroze u krvožilnim bolestima (Flegar-Meštrić, Zlata, MZOS ) ( CroRIS)
006-0061117-1236 - Posttranskripcijsko utišavanje stresnih proteina pomoću siRNA nanoterapije (Barišić, Karmela, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinička bolnica "Merkur",
Veterinarski fakultet, Zagreb

Profili:

Avatar Url Romana Turk (autor)

Avatar Url Zlata Flegar-Meštrić (autor)

Avatar Url Mirna Robić (autor)

Avatar Url Dražen Vnuk (autor)

Avatar Url Ante Svetina (autor)

Avatar Url Dubravka Juretić (autor)

Avatar Url Darko Gereš (autor)

Citiraj ovu publikaciju:

Turk, Romana; Vnuk, Dražen; Svetina, Ante; Flegar-Meštrić, Zlata; Gereš, Darko; Robić, Mirna; Juretić, Dubravka
Serum platelet-activating factor acetylhydrolase (PAF-AH) activity and C-reactive protein (CRP) concentration in pigs after splenectomy and autologous spleen transplantation // 13th ISACP, 10th ESVCP, 8th AECCP & 7th APP Congress : APP Symposium abstracts
Barcelona, Španjolska, 2008. str. 2-2 (poster, međunarodna recenzija, sažetak, znanstveni)
Turk, R., Vnuk, D., Svetina, A., Flegar-Meštrić, Z., Gereš, D., Robić, M. & Juretić, D. (2008) Serum platelet-activating factor acetylhydrolase (PAF-AH) activity and C-reactive protein (CRP) concentration in pigs after splenectomy and autologous spleen transplantation. U: 13th ISACP, 10th ESVCP, 8th AECCP & 7th APP Congress : APP Symposium abstracts.
@article{article, author = {Turk, Romana and Vnuk, Dra\v{z}en and Svetina, Ante and Flegar-Me\v{s}tri\'{c}, Zlata and Gere\v{s}, Darko and Robi\'{c}, Mirna and Jureti\'{c}, Dubravka}, year = {2008}, pages = {2-2}, keywords = {PAF-AH, CRP, acute phase response, pigs, splenectomy, spleen autotransplantation}, title = {Serum platelet-activating factor acetylhydrolase (PAF-AH) activity and C-reactive protein (CRP) concentration in pigs after splenectomy and autologous spleen transplantation}, keyword = {PAF-AH, CRP, acute phase response, pigs, splenectomy, spleen autotransplantation}, publisherplace = {Barcelona, \v{S}panjolska} }
@article{article, author = {Turk, Romana and Vnuk, Dra\v{z}en and Svetina, Ante and Flegar-Me\v{s}tri\'{c}, Zlata and Gere\v{s}, Darko and Robi\'{c}, Mirna and Jureti\'{c}, Dubravka}, year = {2008}, pages = {2-2}, keywords = {PAF-AH, CRP, acute phase response, pigs, splenectomy, spleen autotransplantation}, title = {Serum platelet-activating factor acetylhydrolase (PAF-AH) activity and C-reactive protein (CRP) concentration in pigs after splenectomy and autologous spleen transplantation}, keyword = {PAF-AH, CRP, acute phase response, pigs, splenectomy, spleen autotransplantation}, publisherplace = {Barcelona, \v{S}panjolska} }

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