Naslov
Microwave Synthesis and Spectroscopic Study of 3-Quinoline-substituted alpha-Aminophosphonates

Autori
Juribašić, Marina ; Stella, Laura ; Marinić, Željko ; Vinković, Marijana ; Tušek-Božić, Ljerka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EUCMOS 2008, Book of Abstracts / Musić, S ; Ristić, M ; Krehula, S - Zagreb : Institut Ruđer Bošković, 2008, 66-66

ISBN
978-953-6690-76-3

Skup
EUCMOS 2008, XXIX European Congress on Molecular Spectroscopy

Mjesto i datum
Opatija, Hrvatska, 31.08.2008. - 05.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aminophosphonate; NMR; IR spectroscopy; ESI MS

Sažetak
The synthesis of alpha-aminophosphonate derivatives has attracted current interest in the organic and medicinal chemistry due to important biological and pharmacological properties of these organophosphorus compounds.[1] Another interesting aspect regarding this kind of compounds arises from their ability of forming various types of transition metal complexes, which might also be of interest owing to their biological activity.[2] The classical Kabachnik-Fields reaction, a three-component one-pot reaction of amine, carbonyl compound (aldehyde or ketone) and hydrophosphoryl compound, has proven its great synthetic potential and significance as one of the simplest approaches to alpha-aminophosphonates.[3] We have directed out attention to investigations on the course of microwave-assisted one-pot three-component reaction of quinoline-3-carboxaldehyde and aniline (Scheme 1) as well as 3-aminoquinoline and benzaldehyde (Scheme 2), respectively, with diethyl phosphite. Here, we present 1H and 31P NMR, MS and IR spectroscopic characterization of unusual monoester phosphonate derivatives (2, 3, 5) isolated along with diethyl phosphonates (1, 4).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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