Naslov
The role of alphoid higher order repeats (HORs) in the centromere folding

Autori
Rosandić, Marija ; Glunčić, Matko ; Paar, Vladimir ; Basar, Ivan

Izvornik
Jounal of Theoretical Biology (0022-5193) 254 (2008), 3; 555-560

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA; centromere folding; higher order repeat

Sažetak
Understanding the folding of centromere DNA in the maximally condensed metaphase chromosome remains a basic challenge in cell biology. We propose here a set of structural models with a graphical presentation of alphoid higher order repeat (HOR) distribution in the centromere folding, based on the assumption of encryption key for microtubule-centromere interaction which arises from chromosome-specific crystal-like structure of HORs. Specific HOR leads to a characteristic geometrical pattern which may be responsible for individual microtubule to recognize a specific structure of centromere in each chromosome.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija, Računarstvo

POVEZANOST RADA