Naslov
Eradication of H. pylori in Peptic Ulcers with Four Different Drug Regimens

Autori
Katičić, Miroslava ; Presečki, Vladimir ; Marušić, Marinko ; Prskalo, Marija ; Tićak, Mirjana ; Šabarić, Branka ; Čolić-Cvrlje, Vesna ; Papa, Branko ; Naumovski-Mihalić, Slavica ; Dominis, Mara ; Kalenić, Smilja ; Džebro, Sonja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Gut. 39 (1996), suppl. 3 / S.n. - , 1996, A144-A144

Mjesto i datum
,

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Nije recenziran

Ključne riječi
Helicobacter pylori; therapy; eradication

Sažetak
Aim: Four different therapeutic regimens for H. pylori eradication were compared in patients with gastric (GU) and duodenal ulcer (DU). Methods: 70 GU (M/F 36/34, mean age 57) and 153 DU patients (M/F 90/63, mean age 49) who were positive for H.pylori underwent endoscopy, urease test, histology and serology at the beginning of the study and 4 weeks after the end of the treatment. They were randomly assigned to four treatments groups: A) Omeprazole 20 mg b.d., Amoxicillin 1g b.d. for 14 days (n=57), B) Omeprazole 20 mg b.d., Amoxicillin 1 g b.d. for 14 days, metronidazole 500 b.d. for 10 days (n=63), C) Omeprazole 20 mg b.d., Amoxicillin 1 g b.d., Clarithromycin 500 mg b.d. for 7 days (n=48), D) Omeprazole 20 mg b.d., Amoxicillin 1g b.d., Clarithromycin 500 mg b.d. for 14 days (n=52). Results: Th-groups No.patients Eradicate. (%) Healing (%) Tot. GU DU Tot. GU DU Tot. GU DU Group A 57 23 34 42 52 35 81 83 80 Group B 63 17 46 63 71 61 86 82 87 Group C 48 20 28 83* 80 86 94 95 93 Group D 52 17 35 92* 91 93 98 95 100 (*p<0.05, C and D in comparison with A and B) Conclusion: Combination Omeprazole + Amoxicillin had a low efficacy in the eradication of H.pylori. Two weeks Omeprazole +Amoxicillin+Clarithromycin therapy is the most effective, but one week of the same regimen is effective enough, simple and relatively well tolerated.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA