Pregled bibliografske jedinice broj: 365752
Caspase 3 immunohistochemical expression in borderline and invasive serous ovarian tumours
Caspase 3 immunohistochemical expression in borderline and invasive serous ovarian tumours // Abstracts of the 16th Euroconference on Apoptosis and 5th Swiss Apoptosis Meeting
Bern, Švicarska, 2008. (poster, međunarodna recenzija, sažetak, ostalo)
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Naslov
Caspase 3 immunohistochemical expression in borderline and invasive serous ovarian tumours
Autori
Čarić, Ana ; Poljičanin, Ana ; Košta, Vana ; Prović, Ivana ; Tomić, Snježana ; Vilović, Katarina
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo
Izvornik
Abstracts of the 16th Euroconference on Apoptosis and 5th Swiss Apoptosis Meeting
/ - , 2008
Skup
16th Euroconference on Apoptosis and 5th Swiss Apoptosis Meeting
Mjesto i datum
Bern, Švicarska, 06.09.2008. - 09.09.2008
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
serous ovarian tumours; caspase 3; apoptosis
Sažetak
To demonstrate the immunohistochemical expression of caspase 3 in borderline and invasive serous ovarian tumours. We performed immunohistochemical staining of formalin fixed, paraffin-embedded tissue samples from 40 serous ovarian tumours, using caspase 3 monoclonal antibody, manufactured by R&D Systems (Minneapolis, USA). Apoptotic cells were detected by light microscopy (Olympus BX40). Immunohistochemical results were scored semiquantitatively. Tissue samples contained apoptotic cells with brown stained cytoplasm that were positive to active form of caspase 3. However considerable number of apoptotic cells did not show any caspase 3 positivity in both borderline and invasive serous ovarian tumours. Presence of caspase 3 negative apoptotic cells imply the possibility of activation of different apoptotic pathways in ovarian tumour cells. This implicates that in cancer therapy we should consider targeting divers molecules at the same time for the therapy to be successful.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
216-0000000-0479 - Uloga apoptoze u kancerogenezi ženskog spolnog sustava (Vilović, Katarina, MZOS ) ( CroRIS)
216-0000000-0484 - Dvostruki model ovarijalne kancerogeneze - molekularna i morfološka studija (Tomić, Snježana, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Split
Profili:
Vana Košta
(autor)
Ana Poljičanin
(autor)
Snježana Tomić
(autor)
Katarina Vilović
(autor)
Ana Čarić
(autor)
Ivana Mrklić
(autor)