Naslov
Olive oil polyphenols modify liver polar fatty acid composition and inhibit CCl4-induced hepatotoxicity in Balb/c mice

Autori
Giacometti, Jasminka ; Križan, Hrvoje ; Franjić, Neven ; Buretić-Tomljanović, Alena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Oils, Fats and Lipids in the 3rd Millennium: Challenges, Achievements and Perspectives / - Frankfurt : Euro Fed Lipid, 2008, 509-509

Skup
6th Euro Fed Lipid Congress

Mjesto i datum
Atena, Grčka, 07.09.2008. - 10.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Carbon tetrachloride; lipid peroxidation; liver histology; phospholipid fatty acids; free fatty acids; olive oil polyphenols; TEAC

Sažetak
Olive oil is rich in antioxidant polyphenols that might protect us from oxidative stress-related diseases. Hepatic injury through carbon tetrachloride (CCl4) induced lipid peroxidation is well known and has been extensively used in the experimental models to understand the cellular mechanisms behind oxidative damage and further to evaluate the therapeutic potential of drugs and dietary antioxidants. This study was extended to include the changes in the hepatic phospholipid fatty acid (PL FAs) and free fatty acid profiles (FFAs) caused by single hepatotoxin liver injury (CCl4 treated) as well as to determine antioxidant effects 24 hrs after single olive oil phenolic compounds administration in vivo. Our experimental study showed that olive oil polyphenols significantly reduced fats accumulation in the liver ; alter liver fatty acid metabolism and increasing antioxidant capacity in the serum. So, olive oil polyphenols affect on the regenerating processes in the liver and help in the restoration of the normal liver histology.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA