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Вщ ””€€€€В€щ ш Из Ц”ZН     ””DиU ‚””и Association analysis of G-2548A and A19G polymorphisms in the human leptin gene with obesity Tomas Z1, Smolej Narancic N1, Barbalic M1, Zajc M1, Skaric-Juric T1, Rudan P1, Rudan I2, Campbell H3, Wright AF4 1 Institute for Anthropological Research, Zagreb, Croatia 2 “Andrija Stampar” School of Public Health, School of Medicine, University of Zagreb, Zagreb, Croatia 3 Department of Public Health Sciences, University of Edinburgh, Medical School, Edinburgh, UK 4 MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK Leptin is a protein hormone which plays an important role in the regulation of body adiposity, lipid metabolism and reproductive function. It is primarily secreted by the adipocytes and its concentration in the blood is proportional to the amount of body fat. Many leptin gene polymorphisms have been found, but their association with obesity is still controversial. We tested the polymorphisms G-2548A in promoter region and A19G in intron 1 of leptin gene for association with leptin concentration in the blood and obesity. A population-based association study was conducted in the population isolate of the Eastern Adriatic island of Vis, Croatia. Three hundred and twenty randomly selected subjects from the Vis population were genotyped. Obesity was defined as BMIe"30 kg/m2. The results revealed significant association of G-2548A variant and leptin concentration in a codominant pattern (p=0.026). The ancestral G allele which displays as a minor allele in the Vis population (frequency of 0.44) was associated with higher leptin levels. The leptin concentration was significantly higher in the obese (60.1 ng/ml, N=244), than in the non-obese group (20.7 ng/ml, N=76) and it was more than three times higher in women (44.0 ng/ml) compared to men. However, no association of G-2548A and A19G polymorphisms with obesity was found (with leptin concentration, sex and age as covariates). The results indicate that the studied polymorphisms are not relevant markers for common obesity in this isolated %)*:?EP]_fgz{‡ˆ‘ЁЂЋЌВЕЖТУЭЮЯабвг     8 ? q r t } ™ а б в г к л э     ! = @ R V d ќј№ј№јьјьјьјшршршршршршрмшршршмрјиаЬиаЬШФЬШЬШЬиаРШРЬИРДШДАШАРјьјШјШјh;jЄh(Ÿh”FќhЄ{eH*hЄ{ehqhо …hRU h”FќhRU H*hЂ+hЬaЛh”FќhЬaЛH*h›Eh•xЂhx/ЅhqpЬ6hqpЬh=!нD^_аб r б   ijkЂЃюяїїђђђђђђђђъххххххх$a$$a$gdqpЬgdqpЬ$a$gdqpЬўd r t z   Ђ Я г ф ш   * 8 S „ ‡ ‹ ’ Ÿ   Ї П У о у ю є  ! " # $ 0 5 H ] w ‡   И Й Ы б д и ь ј њ ќ <>@ќјєј№јьјьјшјфјрмимшјајајЬШЬјФјРјМРИРДАЌДЈЄЌ јœЌ˜”œ‹ hžћH*hžћht=hљ3JhЌaОh*ИhУIThуMhAШhяhh/Eбh P№h7BhO0hОЯh3hЋ=•hx/ЅhqpЬ6hŸ hєrhГ њhЄP@hу.Еh’R>h•xЂh”FќhqpЬh`y5@ЂАТЪ"68:<VXftЊикњў(szЄЊњ"&ltƒьєhijЁЂЃя ќєќ№ќьќ№ќ№ќєќшфрмид№ќаЬаЬаШФМФМФИФДАЎДЊІЂžЂмš–мh$Тh€:hЧ)OhqhуMhžћUh ЊhJ4VhQ>Дhc!бh Њ6h ЊhFьhн ^h‚q_hщ*ŠhрuhP/Zh dРhЋ+thТyщh*evh@cwhc!бhulЂ6hulЂ/ population, but were found to influence the leptin concentration which is an obesity-related phenotype. Key words: leptin, polymorphism, isolated populations Topic: No. 7 – Normal variation, population genetics, genetic epidemiology Mode of presentation: POSTER ,1hА‚. 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