Naslov
Decladinosyl-macrolides with anti-inflammatory activity

Autori
Čulić, Ognjen ; Bosnar, Martina ; Alihodžić, Sulejman ; Lazarevski, Gorjana ; Marušić Ištuk, Zorica ; Hutinec, Antun ; Vela, Vanja ; Kragol, Goran

Broj patenta
WO 20061077501 A2

Godina
2006

Datum patenta
27.07.2006

Nositelj prava
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O., ,

Sažetak
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-a, L-1, L-6, L-8, L-2 or L-5 ; and/or inhibitor of excessive lymphocyte proliferation ; and/or excessive granulocyte degranulation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA