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Pregled bibliografske jedinice broj: 362578

The role of antibodies specific for toxic sPLA2s and haemorrhagins in neutralizing potential of antisera raised against Vipera ammodytes ammodytes venom

Halassy, Beata; Habjanec, Lidija; Brgles, Marija; Lang Balija, Maja; Leonardi, Adrijana; Kovačič, Lidija; Prijatelj, Petra; Tomašić, Jelka; Križaj, Igor
The role of antibodies specific for toxic sPLA2s and haemorrhagins in neutralizing potential of antisera raised against Vipera ammodytes ammodytes venom // Comparative Biochemistry and Physiology Part C, 148 (2008), 2; 178-183 doi:10.1016/j.cbpc.2008.05.005 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 362578 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The role of antibodies specific for toxic sPLA2s and haemorrhagins in neutralizing potential of antisera raised against Vipera ammodytes ammodytes venom

Autori
Halassy, Beata ; Habjanec, Lidija ; Brgles, Marija ; Lang Balija, Maja ; Leonardi, Adrijana ; Kovačič, Lidija ; Prijatelj, Petra ; Tomašić, Jelka ; Križaj, Igor

Izvornik
Comparative Biochemistry and Physiology Part C (1532-0456) 148 (2008), 2; 178-183

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Vipera ammodytes ammodytes; Phospholipase A2; Ammodytoxin; Haemorrhagin; Antivenom; ELISA; Toxicity-neutralization potency

Sažetak
The contribution of antibodies directed against the two main toxic groups of proteins in the Vipera ammodytes ammodytes venom, haemorrhagic metalloproteinases (H) and neurotoxic sPLA2s (Atxs), to the overall protective efficacy of the whole venom antisera was investigated. Using ELISA assays we established a high correlation between the protective efficacy of the whole venom antisera in mice and their anti-Atxs antibody content. As the haemorrhage is the prevailing toxic effect of the venom in human, the lack of correlation also with anti-H IgG content exposed that the mouse model might not be optimal to evaluate the neutralizing potential of the venom-specific antisera for human therapy. We further revealed that Atxs and structurally very similar but non-toxic AtnI2 from the venom are not immuno cross-reactive.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija



POVEZANOST RADA

Projekti:
021-0212432-2033 - Imunogeničnost komponenti kompleksnih antigena (Halassy, Beata, MZOS ) ( CroRIS)
021-0212432-2431 - Nove formulacije antigena i imunostimulatora - utjecaj na imunoreakciju (Frkanec, Ruža, MZOS ) ( CroRIS)

Ustanove:
Imunološki zavod d.d.

Profili:

Avatar Url Jelka Tomašić (autor)

Avatar Url Marija Brgles (autor)

Avatar Url Beata Halassy (autor)

Avatar Url Lidija Habjanec (autor)

Avatar Url Maja Lang Balija (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Halassy, Beata; Habjanec, Lidija; Brgles, Marija; Lang Balija, Maja; Leonardi, Adrijana; Kovačič, Lidija; Prijatelj, Petra; Tomašić, Jelka; Križaj, Igor
The role of antibodies specific for toxic sPLA2s and haemorrhagins in neutralizing potential of antisera raised against Vipera ammodytes ammodytes venom // Comparative Biochemistry and Physiology Part C, 148 (2008), 2; 178-183 doi:10.1016/j.cbpc.2008.05.005 (međunarodna recenzija, članak, znanstveni)
Halassy, B., Habjanec, L., Brgles, M., Lang Balija, M., Leonardi, A., Kovačič, L., Prijatelj, P., Tomašić, J. & Križaj, I. (2008) The role of antibodies specific for toxic sPLA2s and haemorrhagins in neutralizing potential of antisera raised against Vipera ammodytes ammodytes venom. Comparative Biochemistry and Physiology Part C, 148 (2), 178-183 doi:10.1016/j.cbpc.2008.05.005.
@article{article, author = {Halassy, Beata and Habjanec, Lidija and Brgles, Marija and Lang Balija, Maja and Leonardi, Adrijana and Kova\v{c}i\v{c}, Lidija and Prijatelj, Petra and Toma\v{s}i\'{c}, Jelka and Kri\v{z}aj, Igor}, year = {2008}, pages = {178-183}, DOI = {10.1016/j.cbpc.2008.05.005}, keywords = {Vipera ammodytes ammodytes, Phospholipase A2, Ammodytoxin, Haemorrhagin, Antivenom, ELISA, Toxicity-neutralization potency}, journal = {Comparative Biochemistry and Physiology Part C}, doi = {10.1016/j.cbpc.2008.05.005}, volume = {148}, number = {2}, issn = {1532-0456}, title = {The role of antibodies specific for toxic sPLA2s and haemorrhagins in neutralizing potential of antisera raised against Vipera ammodytes ammodytes venom}, keyword = {Vipera ammodytes ammodytes, Phospholipase A2, Ammodytoxin, Haemorrhagin, Antivenom, ELISA, Toxicity-neutralization potency} }
@article{article, author = {Halassy, Beata and Habjanec, Lidija and Brgles, Marija and Lang Balija, Maja and Leonardi, Adrijana and Kova\v{c}i\v{c}, Lidija and Prijatelj, Petra and Toma\v{s}i\'{c}, Jelka and Kri\v{z}aj, Igor}, year = {2008}, pages = {178-183}, DOI = {10.1016/j.cbpc.2008.05.005}, keywords = {Vipera ammodytes ammodytes, Phospholipase A2, Ammodytoxin, Haemorrhagin, Antivenom, ELISA, Toxicity-neutralization potency}, journal = {Comparative Biochemistry and Physiology Part C}, doi = {10.1016/j.cbpc.2008.05.005}, volume = {148}, number = {2}, issn = {1532-0456}, title = {The role of antibodies specific for toxic sPLA2s and haemorrhagins in neutralizing potential of antisera raised against Vipera ammodytes ammodytes venom}, keyword = {Vipera ammodytes ammodytes, Phospholipase A2, Ammodytoxin, Haemorrhagin, Antivenom, ELISA, Toxicity-neutralization potency} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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