Naslov
The Role of Polio - Vaccine in Pleural Mesothelioma - An Epidemiological Observation
(The Role of Polio - Vaccine in Pleural Mesothelioma - AN Epidemiological Observation)

Autori
Šarić, Marko ; Ćurin, Katja ; M. Varnai, Veda

Izvornik
Collegium Antropologicum (0350-6134) 32 (2008), 2; 479-483

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
poliovirus vaccine; Simian virus 40; mesothelioma; pleura; asbestos; occupational exposure

Sažetak
From the Croatian Cancer Registry ( period 1991 - 1997 ) 194 malignant pleural mesothelioma patients were collected. According to participation in polio vaccination mass campaign in 1961 that covered the the entire Croatian population aged 3 months to 20 years, mesothelioma patients were divided in vaccinated ( N=58 ), and non - vaccinated ( N=136 )subjects. Significantly higher percentage of those with a history of occupational exposure to asbestos was found in vaccinated ( 79 % ) compared to non - vaccinated group ( 63 % ). This is the opposite to what would be expected if potential SV40 contamination of polio vaccine used had a causative role in the development of the tumour. On the other hand, shorter latency period reflected by very high percentage of 45 -year - old or younger mesothelioma patients in vaccinated group ( 15 out of 58 ), with all of them having a history of occupational asbestos exposure, raises a question for a possible enhancing effect of the vaccine used to asbestos exposure, if it was contaminated with SV40.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA