Naslov
Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients

Autori
Stipčević, Tamara ; Kusačić-Kuna, Sanja ; Deželjin, Martina ; Dodig, Damir ; Koršić, Mirko ; Pivac, Nela ; Muck-Šeler, Dorotea

Izvornik
Hormone research (0301-0163) 71 (2009), 4; 207-212

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Platelet 5-HT ; Platelet MAO B ; hypothyroidism ; thyroxine ; thyroid stimulating hormone

Sažetak
The relationship between hypothalamic-pituitary-thyroid (HPT) axis and serotonergic (5-HT) system is not clear. The aim of the study was to determine platelet biochemical markers (5-HT concentration and monoamine oxidase /MAO-B/ activity) in hypothyroid patients. The study included 25 female medication-free hypothyroid patients in postoperative follow-up after total thyroidectomy due to papillary thyroid carcinoma, who were not treated with synthetic thyroxine (T4) for 4 weeks, and 44 age matched euthyroid healthy women. Platelet 5-HT concentration, platelet MAO-B activity, total T4 and thyroid stimulating hormone (TSH) levels were determined using spectrofluorimetric methods, radioimmunoassay and fluoroimmunoassay, respectively. Hypothyroid patients had significantly higher TSH, significantly lower T4 levels and platelet 5-HT concentration, and unchanged platelet MAO-B acrivity than healthy subjects. A positive correlation between 5-HT concentration and platelet MAO-B activity, and between platelet MAO-B activity and T4 in control subjects was found. Reduced platelet 5-HT concentrations in hypothyroid patients suggests a complex interaction between 5-HT system and HPT axis activity, which could be related to frequent occurrence of depressive symptoms in hypothyroid patients. The determination of platelet 5-HT concentration should be considered as a diagnostic tool for the evaluation of depressive symptoms in hypothyroid patients during hormone withdrawal procedure.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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