Naslov
Cu(II) complexes of nitrogen ligand - oligopeptide conjugates as potential artificial nucleases

Autori
Kirin, Srećko I. ; Happel, Christoph M. ; Klein, Christoph ; Metzler-Nolte, Nils

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of SPS-8, The eight international symposium: Innovation and perspectives in solid phase synthesis and combinatorial libraries / Epton, Rodger - Kingston : Mayflower Worldwide Ltd., 2004, 261-262

Skup
The eight international symposium: Innovation and perspectives in solid phase synthesis and combinatorial libraries

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 02.09.2003. - 06.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
artificial enzymes; copper(II) complexes; peptides; solid phase peptide synthesis

Sažetak
In this work, the nitrogen ligand bpa (bispicolylamine) was conjugated to the oligopeptide nls (nuclear localization signal, PKKKRKV) by solid phase peptide synthesis, yielding bioconjugate 2. The binding of 2 and Cu(II) was studied by UV/VIS and MS and compared with the isolated well-defined simple bpa complex 1Cu. The results indicate similar structural features of 1Cu and the in situ prepared metal bioconjugate 2Cu. At present our efforts are focused on the evaluation of nuclease activity of bioconjugate 2Cu.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA