Naslov
Levamisole : old drug in new clothes

Autori
Božić, Frane ; Šuran, Jelena ; Valpotić, Ivica ; Popović, Maja ; Lacković, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Balkan Congress of Immunology ; u: Macedonian Journal of Medical Sciences / Spiroski, Mirko ; Gogusev, Jean ; Petrov Stojmir - Skopje : Institute of Immunobiology and Human Genetics, Faculty of Medicine, Skopje Republic of Macedonia, 2008, S17-S17

Skup
Balkan Congress of Immunology (5 ; 2008)

Mjesto i datum
Ohrid, Sjeverna Makedonija, 01.06.2008. - 03.06.2008

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
levamisole; adjuvant

Sažetak
Levamisole 2, 3, 5, 6-tetrahydro-6-phenylimidazole (2, 1-b) thiazole, a levo-isomer of tetramisole and member of thioimidazoles, was originally described as a highly effective anthelminthic compound. Soon following that Renoux & Renoux (1971) observed an increased response to Brucella vaccination in mice treated with levamisole, "accusing" the drug for its immunomodulatory property. Since then, many reports have confirmed its immunomodulatory activity and the issue has been well reviewed. In this context, levamisole was the first chemically defined agent shown to have an immunomodulatory effect. This agent possesses antianergic properties and it enhances or restores to normal depressed immune responses acting primarily on cells that participate in cell-mediated immunity such as macrophages and T lymphocytes. It has been used in several human clinical trials as an anticancer drug, and may be used as an adjuvant for preventive vaccines. Although the drug traditionally appeared to act primarily on cellular immune responses, enhancing immune activity specifically in immunocytes whose function is impaired, it was recently shown that levamisole, when administered in combination with some experimental viral, parasitic or bacterial vaccines, enhanced both cellular and antibody response. The potential mechanisms by which levamisole co-administered with these vaccines may affect an immune response are enhanced translocations of specific antigens to the lymph nodes, upregulation of antigen presentation, co-stimulation and cytokine production.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA