Pregled bibliografske jedinice broj: 35758
Polymeric prodrug of gemfibrozil
Polymeric prodrug of gemfibrozil // FIP'99 Abstracts / - (ur.).
Barcelona: -, 1999. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 35758 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Polymeric prodrug of gemfibrozil
Autori
Lovrek, Monika ; Zorc, Branka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
FIP'99 Abstracts
/ - Barcelona, 1999
Skup
World Congres of Pharmacy and Pharmaceutical Sciences '99
Mjesto i datum
Barcelona, Španjolska, 05.09.1999. - 10.09.1999
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
gemfibrozil; polymeric prodrug; poly[a;b-(N-2-hydroxyethyl)-DL-aspartamide] (PHEA)
Sažetak
Gemfibrozil (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid, Gem), a known lipid regulating agent, was bond to poly[a,b-(N-2-hydroxyethyl)-DL-aspartamide] (PHEA) in order to prepare hydrophilic polymeric prodrug. Gemfibrozil (1) was first chemically modified to 2-aminoethyl amide 4 which was allowed to react with poly(2,5)-dioxo-1,3-pyrolidinediyl) (PSI, 5) in the molar ratio of 4 and succinimide units 1:3. The aminolysis was completed with 2-aminoethanol to give water soluble PHEA-Gem conjugate (6) with drug load of 12 %. The conjugate 6 contained gemfibrozil covalently bond by amide link, through nontoxic ethylenediamine spacer.
schema
Izvorni jezik
Engleski
Znanstvena područja
Kemija
