Naslov
Bone metabolism in mares during late pregnancy and early lactation

Autori
Filipović, Natalija ; Stojević, Zvonko ; Prvanović, Nikica ; Tuček, Zvonimir ; Kušec, Vesna ; Beer Ljubić, Blanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 35th European Symposium on Calcified Tissues ; u: Calcified Tissue International 82 (2008) (S1) / Civitelli, Roberto ; Ralston, Stuart H. - New York (NY) : Springer, 2008, S153-S153

Skup
European Symposium on Calcified Tissues (35 ; 2008)

Mjesto i datum
Barcelona, Španjolska, 24.05.2008. - 28.05.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
bone metabolism; mares; pregnancy; lactation

Sažetak
In the present study, the changes in the blood serum parathyroid hormone (PTH), total calcium (Ca), inorganic phosphorus (P), carboxy-terminal telopeptide of type I collagen (CTx), and estradiol (E) concentrations and the bone specific alkaline phosphatase (BALP) activity in mares were investigated with the aim of examining the influence of late pregnancy and lactation on bone metabolism parameters in mares. The research was conducted on mares of Croatian cold-blood horse breed (n = 13), between 3 and 18 years of age. Samples were taken 60± ; ; 10 days and 20± ; ; 10 days before foaling, and 20± ; ; 10 days and 60± ; ; 10 days after foaling (1st, 2nd, 3rd and 4th period, respectively). Significant changes in the concentration of Ca (F=5.26, p<0.005), P (F=7.18, p<0.001), E (F=50.17, p<0.0001) and in the activity of BALP (F=3.27, p<0.05) were observed. Significant changes in the concentration of CTx and PTH were not established. Ca was higher in the 3rd (p<0.05) and 4th (p<0.01) in comparison with the 1st period. P was higher in the 3rd in comparison with the 1st and 2nd period (p<0.01). The activity of BALP was higher in the 4th in comparison with the 1st period (p<0.05). E was lower in the 2nd, 3rd and 4th in comparison with the 1st period, and in the 3rd and 4th in comparison with the 2nd period (p<0.0005). A positive correlation between Ca and P (r=0.42, p<0.005), and between Ca and BALP (r=0.55, p<0.0001) and P and BALP (r=0.29, p<0.05) was found. A negative correlation between E and Ca (r=-0.61, p<0.0001), E and P (r=-0.49, p<0.001), E and BALP (r=-0.46, p<0.005), age and P (r=-0.41, p<0.005) and age and BALP (r=-0.30, p<0.05) was found. Low concentrations of Ca in the 1st period show that demands for minerals in mares were the greatest in late pregnancy, during the fastest growth and mineralization of the foetal skeleton. The lowest activity of BALP in the same period shows that those demands were, at least partially, satisfied by decreased bone synthesis, while bone resorption was not elevated. A negative correlation between E and Ca, P and BALP are in agreement with the known effects of estrogens on decreased bone remodelling. A negative correlation between BALP and age could indicate a decrease in osteoblast activity in older mares.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

Napomena
Doi: 10.1007/s00223-008-9118-5

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