Pregled bibliografske jedinice broj: 355887
The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-((3-Substituted)aminocarbonyl)propanoyl-L-prolines
The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-((3-Substituted)aminocarbonyl)propanoyl-L-prolines // Croatica Chemica Acta, 57 (1984), 2; 251-264 (međunarodna recenzija, članak, znanstveni)
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Naslov
The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-((3-Substituted)aminocarbonyl)propanoyl-L-prolines
Autori
Šunjić, Vitomir ; Šimaga, Šumski ; Vitale, Ljubinka
Izvornik
Croatica Chemica Acta (0011-1643) 57
(1984), 2;
251-264
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Angiotensin converting enzyme ; captopril ; N-(3-(hetero)aryl-aminocarbonyl)propanoyl-L-prolines
Sažetak
Preparations of N-(3-(hetero)aryl-aminocarbonyl)propanoyl-L-proline derivatives 12, 13, 22 and 23 are described. A novel approach consists of fusing (80 - 100 C) N-(hetero)aryl-succinimides (7, 8, 20, 21) with unprotected L-proline and imidazole in the presence of dimethylformamide. In vitro tests for angiotensin converting enzyme (ACE) inhibition showed that all N-(arylaminocarbonyl)-propanoyl-L-prolines (12, 13, 22 and 23) exhibit lower activity than captopril (1), their IC50's ranging from 0.00025 to 0.0033 M.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
