Naslov
Diffusing capacity in patients with GERD

Autori
Bazina, Antonela ; Turkalj, Mirjana ; Plavec, Davor ; Ćaleta, Drago ; Vlašić, Željka ; Erceg, Damir ; Nogalo, Boro

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Pediatric Asthma : Abstracts ; u Allergy 62 (2007) (S1) ; Poster session 167-551 / - Gothenburg, 2007, 417-417

Skup
Pediatric Asthma

Mjesto i datum
Göteborg, Švedska, 09.06.2007. - 13.06.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
diffusing capacity; GERD

Sažetak
Gastroesophageal reflux (GER) is associated with respiratory diseases, particularly with asthma and chronic posterior laryngitis. Continuous aspiration of acid or bulk fluid in to the airways can cause chronic inflammation in the lung parenchyma and alveolar tissue. In the airways it may also cause airway obstruction and gas exchange impairment. To assess the influence of gastroesophageal reflux on lung function and gas diffusion capacity in children with asthma and chronic laryngitis. In 22 children (8– 17 years, both sexes, BMI 16– 27.2) with asthma and chronic laryngitis suggestive for GER, 24-h pH probe was administered. Detailed history, clinical examination, lung function testing, diffusing capacity for CO (DLCO), body pletismography, FENO were performed in all patients during the same visit. All patients were positive for GER (either positive fraction time with pHo4, Boix-Ochoa score, or Johnson-DeMeesters score). DLCO ranged 74– 128% and FENO 6.4– 54.3 ppb. Inverse correlation was found for all reflux indexes with DLCO (_0.71, _0.71, _0.76 ; Po0.001 for all, respectively). Patients with severe reflux (greater than median) had significantly lower values of DLCO (Po0.001). No association was found between reflux indexes and lung function parameters, FENO or BMI. Our results suggest that in patients with significant GER, DLCO should be measured because their dyspnea could be related to gas exchange impairment, despite normal lung function.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

Napomena
Doi: 10.1111/j.1398-9995.2007.01407.x

POVEZANOST RADA