Naslov
C-Reactive protein level in severe stenosis of cerebral arteries

Autori
Flegar-Meštrić, Zlata ; Vrhovski-Hebrang, Danijela ; Preden-Kereković, Vlatka ; Perkov, Sonja ; Hebrang, Andrija ; Grga, Ante ; Januš, Dragutin ; Vidjak, Vinko

Izvornik
Cerebrovascular Diseases (1015-9770) 23 (2007), 5-6; 430-434

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cerebral arteries; stenosis; lipoprotein(a); total homocysteine; total antioxidant status

Sažetak
To determine the significance of the association between the biochemical risk factors for cerebrovascular atherosclerosis (lipid parameters, lipoprotein(a) /Lp(a)/, total homocysteine, total antioxidant status /TAS/ values, trace elements, electrolytes) and the degree of stenosis of cerebral arteries scored by digital subtraction angiography (DSA). Patients and Methods. The investigated group consisted of 35 patients with stenosis less than 50% and 55 patients with stenosis of 50% or more including obliteration, established angiographically. The control group consisted of patients with normal cerebral arteries presented at the ultrasound examination (N=51). The method of examination was the comparison of biochemical risk factors between the examined groups and the control group. Results. The results of lipid parameters did not differ significantly (p>0.05) between patients with stenosis of cerebral arteries and the control group. Significantly elevated total homocysteine concentrations were found in the group with severe stenosis of cerebral arteries (p<0.05). Two independent and significant biochemical risk factors were indentified: Lp(a) for patients with different degrees of stenosis, and TAS for patients with stenosis of more than 50%. The concentrations of trace elements and electrolytes remained unaltered between the groups with cerebrovascular stenosis and the control group. Conclusion. Elevated Lp(a) and low TAS values appear to be the most significant independent biochemical risk factors in the development of cerebrovascular stenosis. Mild hyperhomocysteinemia appears to be an additional discriminating indicator of the severe cerebrovascular stenosis. These results might contribute to the early indentification and recognition of patients with cerebrovascular atherosclerosis.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA