Naslov
Relationship between Helicobacter pylori Infection and Etiology of Liver Cirrhosis: Any Relationship?

Autori
Naumovski-Mihalić, Slavica ; Katičić, Miroslava ; Čolić-Cvrlje, Vesna ; Filipec-Kanižaj, Tajana ; Tićak, Mirjana ; Šabarić, Branka ; Papa, Branko ; Mičetić, Goran ; Škurla, Bruno ; Prskalo, Marija.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Helicobacter / Graham, Y., David - Houston (TX) : Wiley-Blackwell, 2007, 420-420

Skup
XX International Workshop on Helicobacter and related bacteria in chronic digestive inflammation

Mjesto i datum
Istanbul, Turska, 20.09.2007. - 22.09.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; etiology; liver cirrhosis

Sažetak
Aim. To determine the incidence of Helicobacter pylori infection in patients with liver cirrhosis. Methods and Patients. Eighty patients (68M/12F) mean age 48.5 years with cirrhosis of the liver were included in the study. All patients had upper gastroduodenal endoscopy, and gastroduodenal pathology was indentified. H. pylori was confirmed by gastric histology. Etiology of cirrhosis was classified as alcoholic and nonalcoholic. The rate of H. pylori was related to age, etiology, Chil-Pugh grading, levels of serum ammonia, hepatic encephalopathy, and mortality. The patients were divided into two groups: group A with 40 patients with alcohol cirrhosis (AC), and group B with 40 patients with nonalcoholic cirrhosis (NAC). Results. The incidence of H. pylori infection was significantly higher in group B-29 patients from 40 patients (74%) compared with group A-17 patients from 40 patients (42%), p < .001. The levels of serum ammonia was higher in group B-27 patients from 40 patients (68%) compared with group A-16 patients from 40 patients (39%) p <.001. The episodes of hepatic encephalopathy were significantly lower in group A (3.6) compared to group B (8.2) p <.001. In group A, according to the Child Pugh classification, 28% of grade A, 14% of grade B, and 0% of grade C were infected with H. pylori . But in group B, 58% of grade A, 39% of grade B, and 3% of grade C had H. pylori infection p < .001. Conclusion. According to our results, H. pylori infection was an important factor of inducing with high blood ammonia concentration, hepatic encephalopathy, and an inverse relation to the Child Pugh grading in group of patients with nonalcoholic cirrhosis. Our study supports the hypothesis that alcohol has the antimicrobial effects and may facilitate elimination of H. pylori infection in patients with alcohol cirrhosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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