Naslov
The importance of RIA and non-RIA analyses in patients with urolithiasis

Autori
Fosić, Magdolna ; Karner, Ivan ; Kosović, Pašezada ; Mihaljević, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
40 years of Nuclear medicine in Osijek. Osijek, Croatia, 2007.Acta Clinica Croatica, Abstract book.Vol46.Suppl.3.2007 / Mihaljević, Ivan - Zagreb, 2007, 96-96

Skup
40 Years of Nuclear Medicine in Osijek

Mjesto i datum
Osijek, Hrvatska, 15.11.2007. - 17.11.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
RIA and non-RIA analyses ; urolithiasis

Sažetak
According to the bibliographic data, 90% of patients with urolithiasis have some metabolic disorder and 2-17% of them have primary hyperparathyroidism. By performing RIA and non-RIA analyses, insight into the cause of the appearance of the metabolic disorder can be achieved. At the Department of Nuclear Medicine and Radiation Protection of the Osijek University Hospital, metabolic treatment of patients involves the particular RIA and non-RIA analyses. Human parathyroid hormone (PTH) regulates the level of calcium in plasma and urine, and affects the bones, kidneys and small intestine. Cyclic adenosine monophosphate (c-AMP) serves as a second messenger, through which PTH affects the targeted cells (bones and kidneys). 25-OH vitamin D3 and 1, 25(OH)2-vitamin D are responsible for homeostatic mechanisms that regulate the calcium serum level, and for the bone mineralization maintenance. Calcitonin, PTH and 1, 25(OH)2-vitamin D, participate in the regulation of the calcium level. It is possible to examine bone formation by defining the level of bone alkaline phosphatase (BAP), osteocalcin and polypeptide type 1 (PICP) in the serum. Bone resorption is monitored by defining the free pyridine excretion (PYD), deoxypyridinoline (DPD) and all of the cross- linked telepeptides (NTX). The application of RIA and non-RIA analyses is of great importance in discovering of metabolic disorders in patients with urolithiasis, especially in the diagnosis of primary hyperparathyroidism, as well as for monitoring of the treatment results.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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