Naslov
Propolis and its polyphenolic compounds potentiate the effect of Irinotecan on Ehrlich ascites tumor in mice

Autori
Oršolić, Nada ; Horvat Knežević, Anica ; Benković, Vesna ; Brozović, Gordana ; Knežević, Fabijan ; Đikić, Domagoj ; Bašić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Apicultural Congress : Apimondia 2007 : Book of Abstracts / - , 2007

Skup
International Apicultural Congress

Mjesto i datum
Melbourne, Australija, 09.09.2007. - 14.09.2007

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ehrlich ascites tumor; propolis; flavonoids; irinotecan; tumor growth

Sažetak
Effect of anticancer drug Irinotecan combined with water-soluble derivate of propolis (WSDP), ethanolic extract of propolis (EEP), Quercetin, or Naringin, components of propolis, on the growth of Ehrlich ascites tumor (EAT) and life span of tumor bearing Swiss albino mice was studied. Test components were given to mice intraperitonealy (ip) at dose of 100 mg kg-1 for three consecutive days before ip injection of EAT cells (1x106). Irinotecan was administered ip at dose of 50 mg kg-1 on days 1, 13, and 19 after tumor cell inoculation. The results clearly demonstrate synergistic action of Irinotecan with test components on suppression of tumor growth ; test compounds combined with Irinotecan decreased tumor proliferation and increased survival time of treated mice. In addition, ip administered EEP with Irinotecan, significantly (p<0.05) increased life span as compared with Irinotecan given alone. These results suggest the benefits of potential clinical use of propolis preparations and related flavonoids in combination with chemotherapeutic agents in order to maximize antitumor activity and potentially minimize postchemotherapeutic deteriorated reactions.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti

POVEZANOST RADA